Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals

S. Omori, Y. Tanaka, M. Horikoshi, A. Takahashi, K. Hara, H. Hirose, A. Kashiwagi, K. Kaku, R. Kawamori, T. Kadowaki, Y. Nakamura, S. Maeda

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Abstract

Additional susceptibility loci for type 2 diabetes have been identified by a meta-analysis of genome-wide association studies (GWASs) in European populations. To examine further the roles of these new loci, we performed a replication study for the association of these single-nucleotide polymorphism (SNP) loci with the disease in three independent Japanese populations. We genotyped seven of the 11 SNPs that emerged in stage 2 of the meta-analysis for European GWASs (rs864745 in JAZF1, rs12779790 near CDC123/CAMK1D, rs7961581 near TSPAN8/LGR5, rs4607103 near ADAMTS9, rs10923931 in NOTCH2, rs1153188 near DCD and rs9472138 near VEGFA) for three independent Japanese populations (first set, 1,630 type 2 diabetes patients vs 1,064 controls; second set, 1,272 type 2 diabetes patients vs 856 controls; third set, 486 type 2 diabetes patients vs 936 controls) using a TaqMan assay. The association of the SNP loci in each population was analysed using a logistic regression analysis, adjusting for age, sex and BMI, and the data were evaluated by a meta-analysis. A meta-analysis for the three case-control studies identified a nominal association of rs864745 in JAZF1 with type 2 diabetes (OR 1.148, 95% CI 1.034-1.275, p∈=∈0.0098, corrected p∈=∈0.069). The association of other loci did not reach statistically significant levels (nominal p∈>∈0.05). From these results the contribution of these seven loci in conferring susceptibility to type 2 diabetes is considered minor in the Japanese population, if they are present.

Original languageEnglish
Pages (from-to)1554-1560
Number of pages7
JournalDiabetologia
Volume52
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1

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Keywords

  • Association study
  • Japanese
  • SNP
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Omori, S., Tanaka, Y., Horikoshi, M., Takahashi, A., Hara, K., Hirose, H., Kashiwagi, A., Kaku, K., Kawamori, R., Kadowaki, T., Nakamura, Y., & Maeda, S. (2009). Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals. Diabetologia, 52(8), 1554-1560. https://doi.org/10.1007/s00125-009-1397-5