Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population

Minako Imamura, Minoru Iwata, Hiroshi Maegawa, Hirotaka Watada, Hiroshi Hirose, Yasushi Tanaka, Kazuyuki Tobe, Kohei Kaku, Atsunori Kashiwagi, Takashi Kadowaki, Ryuzo Kawamori, Shiro Maeda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aims/Introduction: Genetic risk variants for type 2 diabetes; rs391300-G in SRR and rs17584499-T in PTPRD, have been identified by a genome-wide association study using Han Chinese individuals living in Taiwan. In an attempt to know the effects of these two variants in conferring susceptibility to type 2 diabetes in the Japanese, we carried out a replication study for the association of the two single nucleotide polymorphisms (SNPs) with type 2 diabetes in a Japanese population. Materials and Methods: We genotyped 11,530 Japanese individuals (8,552 type 2 diabetes patients and 2,978 controls) for rs391300 and rs17584499, and analyzed the association of these two SNPs with type 2 diabetes by logistic regression analysis. Results: Neither of the variants was associated with susceptibility to type 2 diabetes in the Japanese population (rs391300-G: odds ratio [OR] = 0.97; 95% confidence interval [CI] 0.91-1.04; P = 0.44; rs17584499-T: OR = 1.04; 95% CI 0.96-1.14; P = 0.34). Adjustment or stratified analysis for age, sex and body mass index (BMI) did not affect the association of these variants with the disease. We did not observe a significant association of the SNPs with any metabolic traits, BMI, fasting plasma glucose, homeostasis model assessment of β-cell function (HOMA-β) and HOMA of insulin resistance (HOMA-IR) (P > 0.05). Conclusions: Neither rs391300 nor rs17584499 had a significant effect on conferring susceptibility to type 2 diabetes in the Japanese population.

Original languageEnglish
Pages (from-to)168-173
Number of pages6
JournalJournal of Diabetes Investigation
Volume4
Issue number2
DOIs
Publication statusPublished - 2013 Mar

Fingerprint

Type 2 Diabetes Mellitus
Population
Single Nucleotide Polymorphism
Body Mass Index
Odds Ratio
Confidence Intervals
Social Adjustment
Genome-Wide Association Study
Taiwan
Insulin Resistance
Fasting
Homeostasis
Logistic Models
Regression Analysis
Glucose

Keywords

  • Genetic association studies
  • Japanese
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population. / Imamura, Minako; Iwata, Minoru; Maegawa, Hiroshi; Watada, Hirotaka; Hirose, Hiroshi; Tanaka, Yasushi; Tobe, Kazuyuki; Kaku, Kohei; Kashiwagi, Atsunori; Kadowaki, Takashi; Kawamori, Ryuzo; Maeda, Shiro.

In: Journal of Diabetes Investigation, Vol. 4, No. 2, 03.2013, p. 168-173.

Research output: Contribution to journalArticle

Imamura, M, Iwata, M, Maegawa, H, Watada, H, Hirose, H, Tanaka, Y, Tobe, K, Kaku, K, Kashiwagi, A, Kadowaki, T, Kawamori, R & Maeda, S 2013, 'Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population', Journal of Diabetes Investigation, vol. 4, no. 2, pp. 168-173. https://doi.org/10.1111/jdi.12017
Imamura, Minako ; Iwata, Minoru ; Maegawa, Hiroshi ; Watada, Hirotaka ; Hirose, Hiroshi ; Tanaka, Yasushi ; Tobe, Kazuyuki ; Kaku, Kohei ; Kashiwagi, Atsunori ; Kadowaki, Takashi ; Kawamori, Ryuzo ; Maeda, Shiro. / Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population. In: Journal of Diabetes Investigation. 2013 ; Vol. 4, No. 2. pp. 168-173.
@article{fd76b0011bfe4f7ba28c300f97362340,
title = "Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population",
abstract = "Aims/Introduction: Genetic risk variants for type 2 diabetes; rs391300-G in SRR and rs17584499-T in PTPRD, have been identified by a genome-wide association study using Han Chinese individuals living in Taiwan. In an attempt to know the effects of these two variants in conferring susceptibility to type 2 diabetes in the Japanese, we carried out a replication study for the association of the two single nucleotide polymorphisms (SNPs) with type 2 diabetes in a Japanese population. Materials and Methods: We genotyped 11,530 Japanese individuals (8,552 type 2 diabetes patients and 2,978 controls) for rs391300 and rs17584499, and analyzed the association of these two SNPs with type 2 diabetes by logistic regression analysis. Results: Neither of the variants was associated with susceptibility to type 2 diabetes in the Japanese population (rs391300-G: odds ratio [OR] = 0.97; 95{\%} confidence interval [CI] 0.91-1.04; P = 0.44; rs17584499-T: OR = 1.04; 95{\%} CI 0.96-1.14; P = 0.34). Adjustment or stratified analysis for age, sex and body mass index (BMI) did not affect the association of these variants with the disease. We did not observe a significant association of the SNPs with any metabolic traits, BMI, fasting plasma glucose, homeostasis model assessment of β-cell function (HOMA-β) and HOMA of insulin resistance (HOMA-IR) (P > 0.05). Conclusions: Neither rs391300 nor rs17584499 had a significant effect on conferring susceptibility to type 2 diabetes in the Japanese population.",
keywords = "Genetic association studies, Japanese, Type 2 diabetes mellitus",
author = "Minako Imamura and Minoru Iwata and Hiroshi Maegawa and Hirotaka Watada and Hiroshi Hirose and Yasushi Tanaka and Kazuyuki Tobe and Kohei Kaku and Atsunori Kashiwagi and Takashi Kadowaki and Ryuzo Kawamori and Shiro Maeda",
year = "2013",
month = "3",
doi = "10.1111/jdi.12017",
language = "English",
volume = "4",
pages = "168--173",
journal = "Journal of Diabetes Investigation",
issn = "2040-1116",
publisher = "Blackwell Publishing Asia Pty Ltd",
number = "2",

}

TY - JOUR

T1 - Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population

AU - Imamura, Minako

AU - Iwata, Minoru

AU - Maegawa, Hiroshi

AU - Watada, Hirotaka

AU - Hirose, Hiroshi

AU - Tanaka, Yasushi

AU - Tobe, Kazuyuki

AU - Kaku, Kohei

AU - Kashiwagi, Atsunori

AU - Kadowaki, Takashi

AU - Kawamori, Ryuzo

AU - Maeda, Shiro

PY - 2013/3

Y1 - 2013/3

N2 - Aims/Introduction: Genetic risk variants for type 2 diabetes; rs391300-G in SRR and rs17584499-T in PTPRD, have been identified by a genome-wide association study using Han Chinese individuals living in Taiwan. In an attempt to know the effects of these two variants in conferring susceptibility to type 2 diabetes in the Japanese, we carried out a replication study for the association of the two single nucleotide polymorphisms (SNPs) with type 2 diabetes in a Japanese population. Materials and Methods: We genotyped 11,530 Japanese individuals (8,552 type 2 diabetes patients and 2,978 controls) for rs391300 and rs17584499, and analyzed the association of these two SNPs with type 2 diabetes by logistic regression analysis. Results: Neither of the variants was associated with susceptibility to type 2 diabetes in the Japanese population (rs391300-G: odds ratio [OR] = 0.97; 95% confidence interval [CI] 0.91-1.04; P = 0.44; rs17584499-T: OR = 1.04; 95% CI 0.96-1.14; P = 0.34). Adjustment or stratified analysis for age, sex and body mass index (BMI) did not affect the association of these variants with the disease. We did not observe a significant association of the SNPs with any metabolic traits, BMI, fasting plasma glucose, homeostasis model assessment of β-cell function (HOMA-β) and HOMA of insulin resistance (HOMA-IR) (P > 0.05). Conclusions: Neither rs391300 nor rs17584499 had a significant effect on conferring susceptibility to type 2 diabetes in the Japanese population.

AB - Aims/Introduction: Genetic risk variants for type 2 diabetes; rs391300-G in SRR and rs17584499-T in PTPRD, have been identified by a genome-wide association study using Han Chinese individuals living in Taiwan. In an attempt to know the effects of these two variants in conferring susceptibility to type 2 diabetes in the Japanese, we carried out a replication study for the association of the two single nucleotide polymorphisms (SNPs) with type 2 diabetes in a Japanese population. Materials and Methods: We genotyped 11,530 Japanese individuals (8,552 type 2 diabetes patients and 2,978 controls) for rs391300 and rs17584499, and analyzed the association of these two SNPs with type 2 diabetes by logistic regression analysis. Results: Neither of the variants was associated with susceptibility to type 2 diabetes in the Japanese population (rs391300-G: odds ratio [OR] = 0.97; 95% confidence interval [CI] 0.91-1.04; P = 0.44; rs17584499-T: OR = 1.04; 95% CI 0.96-1.14; P = 0.34). Adjustment or stratified analysis for age, sex and body mass index (BMI) did not affect the association of these variants with the disease. We did not observe a significant association of the SNPs with any metabolic traits, BMI, fasting plasma glucose, homeostasis model assessment of β-cell function (HOMA-β) and HOMA of insulin resistance (HOMA-IR) (P > 0.05). Conclusions: Neither rs391300 nor rs17584499 had a significant effect on conferring susceptibility to type 2 diabetes in the Japanese population.

KW - Genetic association studies

KW - Japanese

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=84878370204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878370204&partnerID=8YFLogxK

U2 - 10.1111/jdi.12017

DO - 10.1111/jdi.12017

M3 - Article

VL - 4

SP - 168

EP - 173

JO - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

SN - 2040-1116

IS - 2

ER -