TY - JOUR
T1 - Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
AU - Hayashi, T.
AU - Iwamoto, Y.
AU - Kaku, K.
AU - Hirose, H.
AU - Maeda, S.
N1 - Funding Information:
Acknowledgements We would like to thank R. Kawamori (Department of Internal Medicine, Metabolism and Endocrinology, School of Medicine, Juntendo University, Tokyo, Japan), A. Kashiwagi (Department of Medicine, Shiga University of Medical Science, Otsu, Japan), T. Babazono (Diabetes Center, Tokyo Women’s Medical University, Tokyo, Japan) for helpful discussions. We also thank N. Osawa, S. Tsukada, K. Kamiyama and the technical staff of the Laboratory for Diabetic Nephropathy at the SNP Research Centre for their technical assistance. This work was partly supported by the Japanese Millennium Project.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/5
Y1 - 2007/5
N2 - Aims/hypothesis: The transcription factor 7-like 2 gene (TCF7L2) has been shown to be strongly associated with an increased risk of type 2 diabetes in white populations. To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TCF7L2 polymorphisms with type 2 diabetes in a Japanese population. Subjects and methods: We analysed four SNPs (rs12255372, rs7903146, rs7901695 and rs11196205) and one tetranucleotide repeat polymorphism (DG10S478) in 1,630 Japanese subjects with type 2 diabetes and 1,064 control subjects. Results: All investigated polymorphisms were significantly associated with type 2 diabetes, and rs12255372 showed the strongest association (T vs G, χ 2 = 9.20, p = 0.0024, odds ratio = 1.70, 95% CI = 1.20-2.41), although the frequency of the risk allele in our population was much lower than that in white populations. The microsatellite polymorphism showed an almost complete linkage disequilibrium to rs1255372 when the alleles with longer repeats (+8, +12) were considered as minor alleles and showed an association with type 2 diabetes (χ 2 = 5.34, p = 0.021, odds ratio = 1.50, 95% CI = 1.06-2.12). Conclusions/interpretation: These results indicate that TCF7L2 might be a strong candidate for conferring susceptibility to type 2 diabetes across different ethnicities.
AB - Aims/hypothesis: The transcription factor 7-like 2 gene (TCF7L2) has been shown to be strongly associated with an increased risk of type 2 diabetes in white populations. To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TCF7L2 polymorphisms with type 2 diabetes in a Japanese population. Subjects and methods: We analysed four SNPs (rs12255372, rs7903146, rs7901695 and rs11196205) and one tetranucleotide repeat polymorphism (DG10S478) in 1,630 Japanese subjects with type 2 diabetes and 1,064 control subjects. Results: All investigated polymorphisms were significantly associated with type 2 diabetes, and rs12255372 showed the strongest association (T vs G, χ 2 = 9.20, p = 0.0024, odds ratio = 1.70, 95% CI = 1.20-2.41), although the frequency of the risk allele in our population was much lower than that in white populations. The microsatellite polymorphism showed an almost complete linkage disequilibrium to rs1255372 when the alleles with longer repeats (+8, +12) were considered as minor alleles and showed an association with type 2 diabetes (χ 2 = 5.34, p = 0.021, odds ratio = 1.50, 95% CI = 1.06-2.12). Conclusions/interpretation: These results indicate that TCF7L2 might be a strong candidate for conferring susceptibility to type 2 diabetes across different ethnicities.
KW - Association study
KW - Gene polymorphism
KW - Microsatellite marker
KW - TCF7L2
KW - Transcription factor 7-like 2
KW - Type 2 diabetes
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U2 - 10.1007/s00125-007-0618-z
DO - 10.1007/s00125-007-0618-z
M3 - Article
C2 - 17340123
AN - SCOPUS:34147119644
VL - 50
SP - 980
EP - 984
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 5
ER -