Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

T. Hayashi, Y. Iwamoto, K. Kaku, Hiroshi Hirose, S. Maeda

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Aims/hypothesis: The transcription factor 7-like 2 gene (TCF7L2) has been shown to be strongly associated with an increased risk of type 2 diabetes in white populations. To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TCF7L2 polymorphisms with type 2 diabetes in a Japanese population. Subjects and methods: We analysed four SNPs (rs12255372, rs7903146, rs7901695 and rs11196205) and one tetranucleotide repeat polymorphism (DG10S478) in 1,630 Japanese subjects with type 2 diabetes and 1,064 control subjects. Results: All investigated polymorphisms were significantly associated with type 2 diabetes, and rs12255372 showed the strongest association (T vs G, χ 2 = 9.20, p = 0.0024, odds ratio = 1.70, 95% CI = 1.20-2.41), although the frequency of the risk allele in our population was much lower than that in white populations. The microsatellite polymorphism showed an almost complete linkage disequilibrium to rs1255372 when the alleles with longer repeats (+8, +12) were considered as minor alleles and showed an association with type 2 diabetes (χ 2 = 5.34, p = 0.021, odds ratio = 1.50, 95% CI = 1.06-2.12). Conclusions/interpretation: These results indicate that TCF7L2 might be a strong candidate for conferring susceptibility to type 2 diabetes across different ethnicities.

Original languageEnglish
Pages (from-to)980-984
Number of pages5
JournalDiabetologia
Volume50
Issue number5
DOIs
Publication statusPublished - 2007 May

Fingerprint

T Cell Transcription Factor 1
Type 2 Diabetes Mellitus
Population
Genes
Microsatellite Repeats
Alleles
Odds Ratio
Linkage Disequilibrium
Type 1 Diabetes Mellitus
Gene Frequency
Single Nucleotide Polymorphism

Keywords

  • Association study
  • Gene polymorphism
  • Microsatellite marker
  • TCF7L2
  • Transcription factor 7-like 2
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. / Hayashi, T.; Iwamoto, Y.; Kaku, K.; Hirose, Hiroshi; Maeda, S.

In: Diabetologia, Vol. 50, No. 5, 05.2007, p. 980-984.

Research output: Contribution to journalArticle

Hayashi, T. ; Iwamoto, Y. ; Kaku, K. ; Hirose, Hiroshi ; Maeda, S. / Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. In: Diabetologia. 2007 ; Vol. 50, No. 5. pp. 980-984.
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AU - Maeda, S.

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