Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes

Yohei Takahashi, Morio Matsumoto, Tatsuki Karasugi, Koota Watanabe, Kazuhiro Chiba, Noriaki Kawakami, Taichi Tsuji, Koki Uno, Teppei Suzuki, Manabu Ito, Hideki Sudo, Shohei Minami, Toshiaki Kotani, Katsuki Kono, Haruhisa Yanagida, Hiroshi Taneichi, Atsushi Takahashi, Yoshiaki Toyama, Shiro Ikegawa

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Adolescent idiopathic scoliosis (AIS) is a common disorder with a strong genetic predisposition. Associations between AIS and common single nucleotide polymorphisms (SNPs) in estrogen receptor genes have been reported. rs9340799 in the gene for estrogen receptor α (ESR1) is reported to be associated with curve severity in Japanese and with AIS predisposition and curve severity in Chinese. In addition, rs1256120 in the gene for estrogen receptor β (ESR2) is reported to be associated with AIS predisposition and curve severity in Chinese. However, the sample sizes of these previous studies were small, and the associations of these SNPs have not been replicated. To examine the association between AIS and estrogen receptor genes, we investigated the association of rs9340799 and rs1256120 with AIS predisposition and curve severity using a large Japanese population, consisting of 798 AIS patients and 637 sex-matched controls. We found no association of either SNP with AIS predisposition or curve severity in the Japanese population. Considering the statistical power of the present study and the limitations of the previous reports, we conclude that the associations of rs9340799 and rs1256120 with AIS predisposition and curve severity are negative.

Original languageEnglish
Pages (from-to)834-837
Number of pages4
JournalJournal of Orthopaedic Research
Volume29
Issue number6
DOIs
Publication statusPublished - 2011 Jun

Fingerprint

Scoliosis
Estrogen Receptors
Genes
Single Nucleotide Polymorphism
Genetic Predisposition to Disease
Sample Size
Population

Keywords

  • adolescent idiopathic scoliosis
  • curve severity
  • estrogen receptor α
  • estrogen receptor β
  • predisposition

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes. / Takahashi, Yohei; Matsumoto, Morio; Karasugi, Tatsuki; Watanabe, Koota; Chiba, Kazuhiro; Kawakami, Noriaki; Tsuji, Taichi; Uno, Koki; Suzuki, Teppei; Ito, Manabu; Sudo, Hideki; Minami, Shohei; Kotani, Toshiaki; Kono, Katsuki; Yanagida, Haruhisa; Taneichi, Hiroshi; Takahashi, Atsushi; Toyama, Yoshiaki; Ikegawa, Shiro.

In: Journal of Orthopaedic Research, Vol. 29, No. 6, 06.2011, p. 834-837.

Research output: Contribution to journalArticle

Takahashi, Y, Matsumoto, M, Karasugi, T, Watanabe, K, Chiba, K, Kawakami, N, Tsuji, T, Uno, K, Suzuki, T, Ito, M, Sudo, H, Minami, S, Kotani, T, Kono, K, Yanagida, H, Taneichi, H, Takahashi, A, Toyama, Y & Ikegawa, S 2011, 'Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes', Journal of Orthopaedic Research, vol. 29, no. 6, pp. 834-837. https://doi.org/10.1002/jor.21322
Takahashi, Yohei ; Matsumoto, Morio ; Karasugi, Tatsuki ; Watanabe, Koota ; Chiba, Kazuhiro ; Kawakami, Noriaki ; Tsuji, Taichi ; Uno, Koki ; Suzuki, Teppei ; Ito, Manabu ; Sudo, Hideki ; Minami, Shohei ; Kotani, Toshiaki ; Kono, Katsuki ; Yanagida, Haruhisa ; Taneichi, Hiroshi ; Takahashi, Atsushi ; Toyama, Yoshiaki ; Ikegawa, Shiro. / Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes. In: Journal of Orthopaedic Research. 2011 ; Vol. 29, No. 6. pp. 834-837.
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