Report of a case successfully treated with chemo-radiation against local recurrence after gastric cancer surgery

Takahiro Igarashi, Yoshiro Saikawa, Koshi Kumagai, Rieko Nakamura, Tsunehiro Takahashi, Yuya Takeuchi, Yuko Kitagawa

Research output: Contribution to journalArticle

Abstract

A 68-year-old male was diagnosed as type 2 gastric cancer in the upper part of the stomach, then diagnosed as cT2 (MP) N0M0H0P0, cStage I B. Total gastrectomy and splenectomy with D2 lymph node dissection were performed. Final diagnosis including pathology was pT1 (SM) N1M0H0P0, pStage IB, and with his informed consent, an anti-cancer drug, UFT, was given as postoperative adjuvant therapy. Four months after the surgery, a 35-mm sized tumor recurring around the distal region of pancreas was detected by abdominal computed tomography (ACT). Then, combination chemo-radiotherapy using S-1, cisplatin and radiation (50 Gy) was performed. One year after the initial surgery, ACT showed a complete response (CR) of the recurred tumor, while outpatient chemotherapy with S-1+CPT-11 and S-1+paclitaxel was continuously performed, because of elevated CEA. Two years after initial surgery, the CEA value was elevated to 28.4 ng/mL, and so S-1 +docetaxel was applied. The patient is still alive with no sign of lesion recurrence by CT 3 years after initial surgery. Outpatient chemotherapy helped the patient maintain good quality of life. In addition, initial therapy for the recurred tumor including radiation proved to be a powerful way to control local growth of gastric cancer, even if hematogenous/lymphatic spreading of gastric cancer cells might be difficult to suppress with such chemo-radiotherapy.

Original languageEnglish
Pages (from-to)1363-1366
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume36
Issue number8
Publication statusPublished - 2009 Aug

Keywords

  • Chemoradiation therapy
  • Recurrent gastric cancer
  • S-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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