Residual lumbar curvature that developed during adolescence accelerates intervertebral disc degeneration in adulthood

Satoshi Suzuki, Hirokazu Fujiwara, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Eijiro Okada, Nobuyuki Fujita, Mitsuru Yagi, Ayato Nohara, Noriaki Kawakami, Takehiro Michikawa, Masaya Nakamura, Morio Matsumoto, Kota Watanabe

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To elucidate the influence of spinal deformity in adolescent idiopathic scoliosis (AIS) on lumbar intervertebral disc (IVD) degeneration in adulthood using magnetic resonance imaging (MRI). Methods: A total of 102 patients (8 men, 94 women; mean age, 31.4 years) who had developed idiopathic scoliosis at the age of 10–18 years and underwent preoperative lumbar spine MRI at the age of ≥ 20 were included in the study. Twenty volunteers (3 men, 17 women; mean age, 33.6 years) without scoliosis were assessed as controls. We divided the adult scoliosis patients into two groups: Group A consisted of patients with lumbar modifier A, and Group BC consisted of those with modifiers B and C. IVD degeneration from L1/2 to L5/S1 was assessed by MRI. The Scoliosis Research Society-22 (SRS-22) patient questionnaire was used in the patients’ clinical assessment. Results: There were 40 patients in the Group A and 62 in the Group BC. Compared to the control groups, significant IVD degeneration was observed at L2/3 and L3/4 in Group A, and at all levels except for L5/S1 in Group BC. The proportion of degenerated IVDs patients (Grades 1c and 2) was significantly higher in Group BC than those in Group A at L3/L4 and L4/L5. Furthermore, the severity of IVD degeneration was significantly greater in the group BC than in the group A at all levels, except for L5/S1, especially in patients aged > 30 years. The mean scores of all subdomains in the SRS-22 questionnaire were comparable between the two groups. Conclusion: Our study showed that the residual lumbar curvature from AIS may have accelerated IVD degeneration in adulthood, especially in patients aged > 30 years. Level of evidence: III.

Original languageEnglish
JournalSpine Deformity
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Adolescent idiopathic scoliosis
  • Adulthood
  • Intervertebral disc degeneration
  • Lumbar curvature
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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