Residual memory dysfunction in recurrent major depressive disorder - A longitudinal study from Juntendo University Mood Disorder Project

Hitoshi Maeshima, Hajime Baba, Yoshiyuki Nakano, Emi Satomura, Yuki Namekawa, Naoko Takebayashi, Toshihito Suzuki, Masaru Mimura, Heii Arai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Depression may increase the risk of developing Alzheimer's disease. Large cohort studies have shown that recurrent depression is associated with a risk of developing dementia. Other studies have documented smaller hippocampal volume in patients with recurrent depression. It is speculative that a greater risk of developing dementia may result from a higher number of previous depressive episodes. This study compared patients with recurrent and single-episode depression in the remitted stage, and healthy controls to elucidate the impact of the number of depressive episodes on memory. Methods: Logical memory and visual reproduction subtests of the Wechsler Memory Scale-Revised were given to 68 patients with major depressive disorder (MDD) (30 patients with a single episode and residual 38 patients with recurrent multiple episodes) and 57 healthy controls. The patients with MDD received memory assessment at the time of initial remission and at the follow-up period 3 years after remission. Results: At the time of initial remission, scores of both logical memory and visual reproduction subtests were significantly lower in both patient groups compared with healthy controls. At follow-up, memory dysfunction of the single-episode group disappeared, whereas scores in the recurrent group remained significantly lower than those of the single-episode group and controls. Limitations: All patients in the present study were on antidepressant medications. Conclusions: Patients with recurrent MDD with multiple depressive episodes showed residual memory dysfunction even after 3 years of remission. Persistence of memory deficits in the recurrent depression may be a risk factor for developing dementia.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalJournal of Affective Disorders
Volume143
Issue number1-3
DOIs
Publication statusPublished - 2012 Dec 20

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Major Depressive Disorder
Mood Disorders
Longitudinal Studies
Depression
Dementia
Reproduction
Wechsler Scales
Memory Disorders
Antidepressive Agents
Alzheimer Disease
Cohort Studies
Control Groups

Keywords

  • Depression
  • Longitudinal
  • Memory
  • Recurrence
  • Remission

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Residual memory dysfunction in recurrent major depressive disorder - A longitudinal study from Juntendo University Mood Disorder Project. / Maeshima, Hitoshi; Baba, Hajime; Nakano, Yoshiyuki; Satomura, Emi; Namekawa, Yuki; Takebayashi, Naoko; Suzuki, Toshihito; Mimura, Masaru; Arai, Heii.

In: Journal of Affective Disorders, Vol. 143, No. 1-3, 20.12.2012, p. 84-88.

Research output: Contribution to journalArticle

Maeshima, Hitoshi ; Baba, Hajime ; Nakano, Yoshiyuki ; Satomura, Emi ; Namekawa, Yuki ; Takebayashi, Naoko ; Suzuki, Toshihito ; Mimura, Masaru ; Arai, Heii. / Residual memory dysfunction in recurrent major depressive disorder - A longitudinal study from Juntendo University Mood Disorder Project. In: Journal of Affective Disorders. 2012 ; Vol. 143, No. 1-3. pp. 84-88.
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