Residual symptoms in patients with partial versus complete remission of a major depressive disorder episode: Patterns of painful physical symptoms in depression

Eiji Harada, Yoichi Satoi, Toshiaki Kikuchi, Koichiro Watanabe, Levent Alev, Masaru Mimura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: The patterns of residual painful physical symptoms (PPS) and emotional symptoms among patients with partial remission (PR) or complete remission (CR) of a major depressive disorder (MDD) episode were compared. Methods: This is a multicenter, cross-sectional, observational study. Patients who had originally been diagnosed with MDD, were treated with an antidepressant for 12 weeks for that episode, and achieved either PR or CR at study entry were enrolled in the study. Using the 17-item Hamilton Rating Scale for Depression (HAM-D17), PR was defined as a score of ≥8 and ≤18 and CR as a score of ≤7. Residual symptoms were assessed using the Brief Pain Inventory-Short Form (BPI-SF) and the HAM-D17. Results: A total of 323 patients (CR =158, PR =165) were included in the study. Patients in the PR group had a higher mean (standard deviation) score in the HAM-D17 than those in the CR group (11.8 [3.1] and 4.4 [2.0], respectively). BPI-SF results showed that “at least moderate PPS” (score ≥3 on BPI-SF question 5) was significantly more prevalent among patients with PR than those with CR (37.0% vs 16.5%, respectively; odds ratio =3.04; P

Original languageEnglish
Pages (from-to)1599-1607
Number of pages9
JournalNeuropsychiatric Disease and Treatment
Volume12
DOIs
Publication statusPublished - 2016 Jun 30

Keywords

  • Complete remission
  • Depression
  • Major depressive disorder
  • Pain
  • Painful physical symptoms
  • Partial remission
  • Residual symptoms

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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