Resolution of Henoch-Schönlein purpura nephritis after acquired IgA deficiency

Mototsugu Tanaka, George Seki, Kenichi Ishizawa, Junichi Hirahashi, Kenichiro Miura, Takashi Sekine, Tomonosuke Someya, Hiroshi Hataya, Michio Nagata, Toshiro Fujita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a case of Henoch-Schönlein purpura nephritis (HSPN) with acquired IgA deficiency due to parvovirus B19 infection. The patient was diagnosed as having Henoch-Schönlein purpura (HSP) at 6 years old, and subsequently developed macrohematuria and massive proteinuria of 7.4 g/day with decreased creatinine clearance of 70.2 ml/min/1.73 m2 and significantly elevated serum IgA level of 449 mg/dl. The first kidney biopsy yielded the diagnosis of severe HSPN. After the initiation of the immunosuppressive therapy, the patient was infected with parvovirus B19 and developed virus-associated hemophagocytic syndrome (VAHS). Thereafter, the serum level of IgA selectively decreased and remained undetectable until the present time. Repeated kidney biopsies performed over a period of 14 years revealed a remarkable histological improvement in association with stabilization of the patient's kidney function. Considering the severity of initial kidney injury, persistent acquired IgA deficiency was likely to add favorable effects to the immunosuppressive therapy in this patient with HSPN.

Original languageEnglish
Pages (from-to)2355-2358
Number of pages4
JournalPediatric Nephrology
Volume25
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1

    Fingerprint

Keywords

  • Henoch-Schönlein purpura nephritis
  • IgA deficiency
  • IgA nephropathy
  • Parvovirus B19
  • Virus-associated hemophagocytic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Tanaka, M., Seki, G., Ishizawa, K., Hirahashi, J., Miura, K., Sekine, T., Someya, T., Hataya, H., Nagata, M., & Fujita, T. (2010). Resolution of Henoch-Schönlein purpura nephritis after acquired IgA deficiency. Pediatric Nephrology, 25(11), 2355-2358. https://doi.org/10.1007/s00467-010-1568-0