Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation

Nobuyuki Morikawa, Toshiro Honna, Tatsuo Kuroda, Yoshihiro Kitano, Yasushi Fuchimoto, Noriko Kawashima, Kazuteru Kawasaki

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

This report describes a case of Abernethy malformation associated with hepatopulmonary syndrome, which was resolved after shunt ligation. The clinical course indicated that hepatopulmonary syndrome can develop in Abernethy malformation in which liver function and portal pressure is normal, and liver transplantation is not the exclusive therapy for hepatopulmonary syndrome. The levels of endotoxin and endothelin 1 in the shunt blood were high, whereas those of tumor necrosis factor α and interleukin-1β were within reference range. Although pathogenesis of hepatopulmonary syndrome remains unknown, the findings in this case suggest that bacterial translocation as well as elevated endothelin 1 may play a causal role in development of hepatopulmonary syndrome.

Original languageEnglish
Pages (from-to)e35-e38
JournalJournal of Pediatric Surgery
Volume43
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

Keywords

  • Abernethy malformation
  • Endothelin 1
  • Endotoxin
  • Hepatopulmonary syndrome
  • Portosystemic shunt

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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