Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation

Nobuyuki Morikawa, Toshiro Honna, Tatsuo Kuroda, Yoshihiro Kitano, Yasushi Fuchimoto, Noriko Kawashima, Kazuteru Kawasaki

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This report describes a case of Abernethy malformation associated with hepatopulmonary syndrome, which was resolved after shunt ligation. The clinical course indicated that hepatopulmonary syndrome can develop in Abernethy malformation in which liver function and portal pressure is normal, and liver transplantation is not the exclusive therapy for hepatopulmonary syndrome. The levels of endotoxin and endothelin 1 in the shunt blood were high, whereas those of tumor necrosis factor α and interleukin-1β were within reference range. Although pathogenesis of hepatopulmonary syndrome remains unknown, the findings in this case suggest that bacterial translocation as well as elevated endothelin 1 may play a causal role in development of hepatopulmonary syndrome.

Original languageEnglish
JournalJournal of Pediatric Surgery
Volume43
Issue number2
DOIs
Publication statusPublished - 2008 Feb
Externally publishedYes

Fingerprint

Hepatopulmonary Syndrome
Surgical Portasystemic Shunt
Ligation
Pediatrics
Endothelin-1
Bacterial Translocation
Portal Pressure
Interleukin-1
Endotoxins
Liver Transplantation
Reference Values
Tumor Necrosis Factor-alpha
Liver

Keywords

  • Abernethy malformation
  • Endothelin 1
  • Endotoxin
  • Hepatopulmonary syndrome
  • Portosystemic shunt

ASJC Scopus subject areas

  • Surgery

Cite this

Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation. / Morikawa, Nobuyuki; Honna, Toshiro; Kuroda, Tatsuo; Kitano, Yoshihiro; Fuchimoto, Yasushi; Kawashima, Noriko; Kawasaki, Kazuteru.

In: Journal of Pediatric Surgery, Vol. 43, No. 2, 02.2008.

Research output: Contribution to journalArticle

Morikawa, Nobuyuki ; Honna, Toshiro ; Kuroda, Tatsuo ; Kitano, Yoshihiro ; Fuchimoto, Yasushi ; Kawashima, Noriko ; Kawasaki, Kazuteru. / Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation. In: Journal of Pediatric Surgery. 2008 ; Vol. 43, No. 2.
@article{eb4e22956cf143359c1b36bd9e7427d4,
title = "Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation",
abstract = "This report describes a case of Abernethy malformation associated with hepatopulmonary syndrome, which was resolved after shunt ligation. The clinical course indicated that hepatopulmonary syndrome can develop in Abernethy malformation in which liver function and portal pressure is normal, and liver transplantation is not the exclusive therapy for hepatopulmonary syndrome. The levels of endotoxin and endothelin 1 in the shunt blood were high, whereas those of tumor necrosis factor α and interleukin-1β were within reference range. Although pathogenesis of hepatopulmonary syndrome remains unknown, the findings in this case suggest that bacterial translocation as well as elevated endothelin 1 may play a causal role in development of hepatopulmonary syndrome.",
keywords = "Abernethy malformation, Endothelin 1, Endotoxin, Hepatopulmonary syndrome, Portosystemic shunt",
author = "Nobuyuki Morikawa and Toshiro Honna and Tatsuo Kuroda and Yoshihiro Kitano and Yasushi Fuchimoto and Noriko Kawashima and Kazuteru Kawasaki",
year = "2008",
month = "2",
doi = "10.1016/j.jpedsurg.2007.11.001",
language = "English",
volume = "43",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Resolution of hepatopulmonary syndrome after ligation of a portosystemic shunt in a pediatric patient with an Abernethy malformation

AU - Morikawa, Nobuyuki

AU - Honna, Toshiro

AU - Kuroda, Tatsuo

AU - Kitano, Yoshihiro

AU - Fuchimoto, Yasushi

AU - Kawashima, Noriko

AU - Kawasaki, Kazuteru

PY - 2008/2

Y1 - 2008/2

N2 - This report describes a case of Abernethy malformation associated with hepatopulmonary syndrome, which was resolved after shunt ligation. The clinical course indicated that hepatopulmonary syndrome can develop in Abernethy malformation in which liver function and portal pressure is normal, and liver transplantation is not the exclusive therapy for hepatopulmonary syndrome. The levels of endotoxin and endothelin 1 in the shunt blood were high, whereas those of tumor necrosis factor α and interleukin-1β were within reference range. Although pathogenesis of hepatopulmonary syndrome remains unknown, the findings in this case suggest that bacterial translocation as well as elevated endothelin 1 may play a causal role in development of hepatopulmonary syndrome.

AB - This report describes a case of Abernethy malformation associated with hepatopulmonary syndrome, which was resolved after shunt ligation. The clinical course indicated that hepatopulmonary syndrome can develop in Abernethy malformation in which liver function and portal pressure is normal, and liver transplantation is not the exclusive therapy for hepatopulmonary syndrome. The levels of endotoxin and endothelin 1 in the shunt blood were high, whereas those of tumor necrosis factor α and interleukin-1β were within reference range. Although pathogenesis of hepatopulmonary syndrome remains unknown, the findings in this case suggest that bacterial translocation as well as elevated endothelin 1 may play a causal role in development of hepatopulmonary syndrome.

KW - Abernethy malformation

KW - Endothelin 1

KW - Endotoxin

KW - Hepatopulmonary syndrome

KW - Portosystemic shunt

UR - http://www.scopus.com/inward/record.url?scp=38949183686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38949183686&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2007.11.001

DO - 10.1016/j.jpedsurg.2007.11.001

M3 - Article

VL - 43

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 2

ER -