Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

Rina Takamiya; Koichi Fukunaga; Makoto Arita; Jun Miyata; Hiroyuki Seki; Naoto Minematsu; Makoto Suematsu; Koichiro Asano

doi:10.1016/j.fob.2012.10.001

Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

Rina Takamiya, Koichi Fukunaga, Makoto Arita, Jun Miyata, Hiroyuki Seki, Naoto Minematsu, Makoto Suematsu, Koichiro Asano

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.

Original language	English
Pages (from-to)	328-333
Number of pages	6
Journal	FEBS Open Bio
Volume	2
DOIs	https://doi.org/10.1016/j.fob.2012.10.001
Publication status	Published - 2012
Externally published	Yes

Keywords

Cigarette smoke
Macrophage
Reactive oxygen species
Resolvin E1

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.fob.2012.10.001

Cite this

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title = "Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress",

abstract = "Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.",

keywords = "Cigarette smoke, Macrophage, Reactive oxygen species, Resolvin E1",

author = "Rina Takamiya and Koichi Fukunaga and Makoto Arita and Jun Miyata and Hiroyuki Seki and Naoto Minematsu and Makoto Suematsu and Koichiro Asano",

year = "2012",

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language = "English",

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T1 - Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

AU - Takamiya, Rina

AU - Fukunaga, Koichi

AU - Arita, Makoto

AU - Miyata, Jun

AU - Seki, Hiroyuki

AU - Minematsu, Naoto

AU - Suematsu, Makoto

AU - Asano, Koichiro

PY - 2012

Y1 - 2012

N2 - Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.

AB - Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.

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KW - Macrophage

KW - Reactive oxygen species

KW - Resolvin E1

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JF - FEBS Open Bio

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Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

Abstract

Keywords

ASJC Scopus subject areas

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