Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

Rina Takamiya, Koichi Fukunaga, Makoto Arita, Jun Miyata, Hiroyuki Seki, Naoto Minematsu, Makoto Suematsu, Koichiro Asano

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalFEBS Open Bio
Publication statusPublished - 2012
Externally publishedYes


  • Cigarette smoke
  • Macrophage
  • Reactive oxygen species
  • Resolvin E1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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