Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers

An overview of their protective roles in catabasis

Charles N. Serhan, Katherine Gotlinger, Song Hong, Makoto Arita

Research output: Contribution to journalReview article

226 Citations (Scopus)

Abstract

The molecular basis for the beneficial impact of essential omega-3 fatty acids is of considerable interest. Recently, novel mediators generated from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that displayed potent bioactions were first identified in resolving inflammatory exudates [J. Exp. Med. 192 (2000) 1197; J. Exp. Med. 196 (2002) 1025] and in tissues enriched with DHA [J. Exp. Med. 196 (2002) 1025; J. Biol. Chem. 278 (2003) 14677]. The trivial names Resolvin (resolution phase interaction products) and docosatrienes were introduced for the bioactive compounds belonging to these novel series because they demonstrate potent anti-inflammatory and immunoregulatory actions. The compounds derived from eicosapentaenoic acid carrying potent biological actions (i.e., 1-10 nM range) are designated E series, given their EPA precursor, and denoted as Resolvins of the E series (Resolvin E1 or RvE1), and those biosynthesized from the precursor docosahexaenoic acid are Resolvins of the D series (Resolvin D1 or RvD1). Bioactive members from DHA with conjugated triene structures are docosatrienes (DT) that are immunoregulatory [J. Exp. Med. 196 (2002) 1025; J. Biol. Chem. 278 (2003) 14677], and neuroprotective [J. Biol. Chem., 278 (2003) 43807; Proc. Natl. Acad. Sci. U.S.A. [submitted for publication]] and are termed neuroprotectins. The specific receptors for these novel bioactive products from omega-3 EPA and DHA are abbreviated Resolvin D receptors (i.e., ResoDR1), Resolvin E receptor (ResoER1; RER1), and neuroprotectin D receptors (NPDR), respectively, in recognition of their respective cognate ligands. Aspirin treatment impacts biosynthesis of these compounds and a related series by triggering endogenous formation of the 17R-D series Resolvins and docosatrienes. These novel epimers are denoted as aspirin-triggered (AT)-RvDs and -DTs, and possess potent anti-inflammatory actions in vivo essentially equivalent to their 17S series pathway products. Here, we provide a syntomy overview of the formation and actions of these newly uncovered pathways and products as well as highlight their role(s) as endogenous protective mediators generated in anti-inflammation and catabasis.

Original languageEnglish
Pages (from-to)155-172
Number of pages18
JournalProstaglandins and Other Lipid Mediators
Volume73
Issue number3-4
DOIs
Publication statusPublished - 2004 Apr
Externally publishedYes

Fingerprint

Docosahexaenoic Acids
Eicosapentaenoic Acid
Aspirin
Anti-Inflammatory Agents
Essential Fatty Acids
Biosynthesis
Omega-3 Fatty Acids
Exudates and Transudates
Names
Publications
Tissue
Ligands
Inflammation
5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid

Keywords

  • Bioactive lipids
  • Essential fatty acids
  • Fish oils
  • Inflammation
  • Neutrophils
  • Omega-3
  • Resolution

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers : An overview of their protective roles in catabasis. / Serhan, Charles N.; Gotlinger, Katherine; Hong, Song; Arita, Makoto.

In: Prostaglandins and Other Lipid Mediators, Vol. 73, No. 3-4, 04.2004, p. 155-172.

Research output: Contribution to journalReview article

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