Response-oriented preemptive therapy against cytomegalovirus disease with low-dose ganciclovir: A prospective evaluation

Yoshinobu Kanda, Shin Mineishi, Takeshi Saito, Akiko Saito, Mutsuko Ohnishi, Hironari Niiya, Aki Chizuka, Kunihisa Nakai, Toshio Takeuchi, Hiroshi Matsubara, Atsushi Makimoto, Ryuji Tanosaki, Hideo Kunitoh, Kensei Tobinai, Yoichi Takaue

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background. Preemptive therapy against cytomegalovirus (CMV) disease has succeeded in reducing the incidence of CMV disease, but the toxicity of ganciclovir remains problematic. Methods. We prospectively evaluated the efficacy and toxicity of a preemptive protocol with ganciclovir at a reduced initial dose in 40 patients who achieved engraftment after allogeneic hematopoietic stem cell transplantation. Results. Twenty-three (58%) patients had high-risk features, including transplant from an HLA-mismatched or unrelated donor, or associated acute graft-versus-host disease. CMV antigenemia assay was performed weekly, and ganciclovir was started in a risk-adapted manner, in which the initial dose of ganciclovir was fixed at 5 mg/kg/d and then adjusted based on the results of a weekly CMV antigenemia assay. In this protocol, 23 (58%) patients demonstrated positive antigenemia, and 19 (48%) received a preemptive administration of ganciclovir. Only one patient had CMV disease in the gastrointestinal system, which was successfully treated with a regular therapeutic dose of ganciclovir. Consequently, the total dose of ganciclovir was significantly less than that in a previous protocol using the conventional double dose (5 mg/kg twice daily) of ganciclovir (134 mg/kg vs. 190 mg/kg on average, P=0.046). There were no significant toxicities attributed to ganciclovir, except for neutropenia <0.5 × 109/L, which developed in three patients for 3, 4, and 14 days, respectively, with granulocyte colony-stimulating factor support. Conclusion. Preemptive therapy with a low initial dose of ganciclovir appeared to be effective even in high-risk patients. Further randomized controlled trial is warranted.

Original languageEnglish
Pages (from-to)568-572
Number of pages5
JournalTransplantation
Volume73
Issue number4
DOIs
Publication statusPublished - 2002 Feb 27
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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