Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease

Xin Li, Irina Leonardi, Alexa Semon, Itai Doron, Iris H. Gao, Gregory Garbès Putzel, Youngjun Kim, Hiroki Kabata, David Artis, William D. Fiers, Amanda E. Ramer-Tait, Iliyan D. Iliev

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

How mycobiota influence immunity in gut distal sites is not well understood. Li et al. developed protocols for gut-targeted depletion of phagocytes and mycobiota-free mice to investigate the influence of fungi on gut-lung crosstalk. They reveal that intestinal phagocytes sense fungal dysbiosis and mediate gut-lung-directed immunity to aggravate allergic airway disease.

Original languageEnglish
Pages (from-to)847-856.e4
JournalCell Host and Microbe
Volume24
Issue number6
DOIs
Publication statusPublished - 2018 Dec 12
Externally publishedYes

Keywords

  • CX3CR1 mononuclear phagocytes
  • fungi
  • gut-lung axis
  • mycobiome
  • mycobiota dysbiosis

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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  • Cite this

    Li, X., Leonardi, I., Semon, A., Doron, I., Gao, I. H., Putzel, G. G., Kim, Y., Kabata, H., Artis, D., Fiers, W. D., Ramer-Tait, A. E., & Iliev, I. D. (2018). Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease Cell Host and Microbe, 24(6), 847-856.e4. https://doi.org/10.1016/j.chom.2018.11.003