Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population

Tomonori Okamura, Takehito Hayakawa, Takashi Kadowaki, Yoshikuni Kita, Akira Okayama, Paul Elliott, Hirotsugu Ueshima

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Background Several prospective studies have reported resting heart rate (HR) to be a risk factor for certain cause-specific death, together with sex- or age-specific differences in the effects of HR on death. However, there have been few prospective data from non-Western populations. Methods Cohort study, over 16.5 years to date of death or end of follow-up (November 15, 1998) involving 8800 men and women ≥30 years of age randomly selected throughout Japan, who participated in the National Survey on Circulatory Disorders in 1980. Resting HR was determined from 3 consecutive intervals between R waves on the 12-lead electrocardiogram. Results For middle-aged men (30 to 59 years of age), in the highest quartile of HR, there was a significant positive association with cardiovascular (RR, 2.55; 95% CI, 1.22 to 5.31) and all-cause death (RR, 1.45; 95% CI, 1.06 to 2.00). For middle-aged women, in the highest quartile, there was a significant positive association with noncancer, noncardiovascular (RR, 2.41; 95% CI, 1.04 to 5.59), and all-cause death (RR, 1.94; 95% CI, 1.26 to 3.01). Resting HR also showed a significant positive association with cardiac events but not to stroke. These relations were not evident for elderly subjects (≥60 years of age). Results were not affected when deaths within the first 5 years of follow-up were excluded, except for noncancer, noncardiovascular death. Conclusions High resting HR is an independent predictor of long-term death in the Japanese general population.

Original languageEnglish
Pages (from-to)1024-1032
Number of pages9
JournalAmerican Heart Journal
Volume147
Issue number6
DOIs
Publication statusPublished - 2004 Jun
Externally publishedYes

Fingerprint

Cause of Death
Cohort Studies
Heart Rate
Population
Japan
Electrocardiography
Stroke
Prospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population. / Okamura, Tomonori; Hayakawa, Takehito; Kadowaki, Takashi; Kita, Yoshikuni; Okayama, Akira; Elliott, Paul; Ueshima, Hirotsugu.

In: American Heart Journal, Vol. 147, No. 6, 06.2004, p. 1024-1032.

Research output: Contribution to journalArticle

Okamura, Tomonori ; Hayakawa, Takehito ; Kadowaki, Takashi ; Kita, Yoshikuni ; Okayama, Akira ; Elliott, Paul ; Ueshima, Hirotsugu. / Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population. In: American Heart Journal. 2004 ; Vol. 147, No. 6. pp. 1024-1032.
@article{09ad4de070704067a87de6ffe2a61b2b,
title = "Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population",
abstract = "Background Several prospective studies have reported resting heart rate (HR) to be a risk factor for certain cause-specific death, together with sex- or age-specific differences in the effects of HR on death. However, there have been few prospective data from non-Western populations. Methods Cohort study, over 16.5 years to date of death or end of follow-up (November 15, 1998) involving 8800 men and women ≥30 years of age randomly selected throughout Japan, who participated in the National Survey on Circulatory Disorders in 1980. Resting HR was determined from 3 consecutive intervals between R waves on the 12-lead electrocardiogram. Results For middle-aged men (30 to 59 years of age), in the highest quartile of HR, there was a significant positive association with cardiovascular (RR, 2.55; 95{\%} CI, 1.22 to 5.31) and all-cause death (RR, 1.45; 95{\%} CI, 1.06 to 2.00). For middle-aged women, in the highest quartile, there was a significant positive association with noncancer, noncardiovascular (RR, 2.41; 95{\%} CI, 1.04 to 5.59), and all-cause death (RR, 1.94; 95{\%} CI, 1.26 to 3.01). Resting HR also showed a significant positive association with cardiac events but not to stroke. These relations were not evident for elderly subjects (≥60 years of age). Results were not affected when deaths within the first 5 years of follow-up were excluded, except for noncancer, noncardiovascular death. Conclusions High resting HR is an independent predictor of long-term death in the Japanese general population.",
author = "Tomonori Okamura and Takehito Hayakawa and Takashi Kadowaki and Yoshikuni Kita and Akira Okayama and Paul Elliott and Hirotsugu Ueshima",
year = "2004",
month = "6",
doi = "10.1016/j.ahj.2003.12.020",
language = "English",
volume = "147",
pages = "1024--1032",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population

AU - Okamura, Tomonori

AU - Hayakawa, Takehito

AU - Kadowaki, Takashi

AU - Kita, Yoshikuni

AU - Okayama, Akira

AU - Elliott, Paul

AU - Ueshima, Hirotsugu

PY - 2004/6

Y1 - 2004/6

N2 - Background Several prospective studies have reported resting heart rate (HR) to be a risk factor for certain cause-specific death, together with sex- or age-specific differences in the effects of HR on death. However, there have been few prospective data from non-Western populations. Methods Cohort study, over 16.5 years to date of death or end of follow-up (November 15, 1998) involving 8800 men and women ≥30 years of age randomly selected throughout Japan, who participated in the National Survey on Circulatory Disorders in 1980. Resting HR was determined from 3 consecutive intervals between R waves on the 12-lead electrocardiogram. Results For middle-aged men (30 to 59 years of age), in the highest quartile of HR, there was a significant positive association with cardiovascular (RR, 2.55; 95% CI, 1.22 to 5.31) and all-cause death (RR, 1.45; 95% CI, 1.06 to 2.00). For middle-aged women, in the highest quartile, there was a significant positive association with noncancer, noncardiovascular (RR, 2.41; 95% CI, 1.04 to 5.59), and all-cause death (RR, 1.94; 95% CI, 1.26 to 3.01). Resting HR also showed a significant positive association with cardiac events but not to stroke. These relations were not evident for elderly subjects (≥60 years of age). Results were not affected when deaths within the first 5 years of follow-up were excluded, except for noncancer, noncardiovascular death. Conclusions High resting HR is an independent predictor of long-term death in the Japanese general population.

AB - Background Several prospective studies have reported resting heart rate (HR) to be a risk factor for certain cause-specific death, together with sex- or age-specific differences in the effects of HR on death. However, there have been few prospective data from non-Western populations. Methods Cohort study, over 16.5 years to date of death or end of follow-up (November 15, 1998) involving 8800 men and women ≥30 years of age randomly selected throughout Japan, who participated in the National Survey on Circulatory Disorders in 1980. Resting HR was determined from 3 consecutive intervals between R waves on the 12-lead electrocardiogram. Results For middle-aged men (30 to 59 years of age), in the highest quartile of HR, there was a significant positive association with cardiovascular (RR, 2.55; 95% CI, 1.22 to 5.31) and all-cause death (RR, 1.45; 95% CI, 1.06 to 2.00). For middle-aged women, in the highest quartile, there was a significant positive association with noncancer, noncardiovascular (RR, 2.41; 95% CI, 1.04 to 5.59), and all-cause death (RR, 1.94; 95% CI, 1.26 to 3.01). Resting HR also showed a significant positive association with cardiac events but not to stroke. These relations were not evident for elderly subjects (≥60 years of age). Results were not affected when deaths within the first 5 years of follow-up were excluded, except for noncancer, noncardiovascular death. Conclusions High resting HR is an independent predictor of long-term death in the Japanese general population.

UR - http://www.scopus.com/inward/record.url?scp=3042851927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042851927&partnerID=8YFLogxK

U2 - 10.1016/j.ahj.2003.12.020

DO - 10.1016/j.ahj.2003.12.020

M3 - Article

VL - 147

SP - 1024

EP - 1032

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 6

ER -