Resting-state isolated effective connectivity of the cingulate cortex as a neurophysiological biomarker in patients with severe treatment-resistant schizophrenia

Masataka Wada, Shinichiro Nakajima, Ryosuke Tarumi, Fumi Masuda, Takahiro Miyazaki, Sakiko Tsugawa, Kamiyu Ogyu, Shiori Honda, Karin Matsushita, Yudai Kikuchi, Shinya Fujii, Daniel M. Blumberger, Zafiris J. Daskalakis, Masaru Mimura, Yoshihiro Noda

Research output: Contribution to journalArticle

Abstract

Background: The neural basis of treatment-resistant schizophrenia (TRS) remains unclear. Previous neuroimaging studies suggest that aberrant connectivity between the anterior cingulate cortex (ACC) and default mode network (DMN) may play a key role in the pathophysiology of TRS. Thus, we aimed to examine the connectivity between the ACC and posterior cingulate cortex (PCC), a hub of the DMN, computing isolated effective coherence (iCoh), which represents causal effective connectivity. Methods: Resting-state electroencephalogram with 19 channels was acquired from seventeen patients with TRS and thirty patients with non-TRS (nTRS). The iCoh values between the PCC and ACC were calculated using sLORETA software. We conducted four-way analyses of variance (ANOVAs) for iCoh values with group as a between-subject factor and frequency, directionality, and laterality as within-subject factors and post-hoc independent t-tests. Results: The ANOVA and post-hoc t-tests for the iCoh ratio of directionality from PCC to ACC showed significant findings in delta (t45 = 7.659, p = 0.008) and theta (t45 = 8.066, p = 0.007) bands in the left side (TRS < nTRS). Conclusion: Left delta and theta PCC and ACC iCoh ratio may represent a neurophysiological basis of TRS. Given the preliminary nature of this study, these results warrant further study to confirm the importance of iCoh as a clinical indicator for treatment-resistance.

Original languageEnglish
Article number89
Pages (from-to)1-12
Number of pages12
JournalJournal of Personalized Medicine
Volume10
Issue number3
DOIs
Publication statusPublished - 2020 Sep

Keywords

  • Anterior cingulate cortex
  • Causal effective connectivity
  • Default mode network
  • Isolated effective coherence
  • Posterior cingulate cortex
  • Resting-state electroencephalography
  • Treatment-resistant schizophrenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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    Wada, M., Nakajima, S., Tarumi, R., Masuda, F., Miyazaki, T., Tsugawa, S., Ogyu, K., Honda, S., Matsushita, K., Kikuchi, Y., Fujii, S., Blumberger, D. M., Daskalakis, Z. J., Mimura, M., & Noda, Y. (2020). Resting-state isolated effective connectivity of the cingulate cortex as a neurophysiological biomarker in patients with severe treatment-resistant schizophrenia. Journal of Personalized Medicine, 10(3), 1-12. [89]. https://doi.org/10.3390/jpm10030089