Resting-state pallidal-cortical oscillatory couplings in patients with predominant phasic and tonic dystonia

Fusako Yokochi, Kenji Kato, Hirokazu Iwamuro, Tsutomu Kamiyama, Katsuo Kimura, Akihiro Yugeta, Ryoichi Okiyama, Makoto Taniguchi, Satoko Kumada, Junichi Ushiba

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Pallidal deep brain stimulation (DBS) improves the symptoms of dystonia. The improvement processes of dystonic movements (phasic symptoms) and tonic symptoms differ. Phasic symptoms improve rapidly after starting DBS treatment, but tonic symptoms improve gradually. This difference implies distinct neuronal mechanisms for phasic and tonic symptoms in the underlying cortico-basal ganglia neuronal network. Phasic symptoms are related to the pallido-thalamo-cortical pathway. The pathway related to tonic symptoms has been assumed to be different from that for phasic symptoms. In the present study, local field potentials of the globus pallidus internus (GPi) and globus pallidus externus (GPe) and electroencephalograms from the motor cortex (MCx) were recorded in 19 dystonia patients to analyze the differences between the two types of symptoms. The 19 patients were divided into two groups, 10 with predominant phasic symptoms (phasic patients) and 9 with predominant tonic symptoms (tonic patients). To investigate the distinct features of oscillations and functional couplings across the GPi, GPe, and MCx by clinical phenotype, power and coherence were calculated over the delta (2-4 Hz), theta (5-7 Hz), alpha (8-13 Hz), and beta (14-35 Hz) frequencies. In phasic patients, the alpha spectral peaks emerged in the GPi oscillatory activities, and alpha GPi coherence with the GPe and MCx was higher than in tonic patients. On the other hand, delta GPi oscillatory activities were prominent, and delta GPi-GPe coherence was significantly higher in tonic than in phasic patients. However, there was no significant delta coherence between the GPi/GPe and MCx in tonic patients. These results suggest that different pathophysiological cortico-pallidal oscillations are related to tonic and phasic symptoms.

Original languageEnglish
Article number375
JournalFrontiers in Neurology
Volume9
Issue numberMAY
DOIs
Publication statusPublished - 2018 May 31

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Globus Pallidus
Dystonia
Motor Cortex
Deep Brain Stimulation
Basal Ganglia
Electroencephalography

Keywords

  • Coherence
  • Deep brain stimulation
  • Dystonia
  • Globus pallidus
  • Local field potentials
  • Motor cortex
  • Resting-state

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Resting-state pallidal-cortical oscillatory couplings in patients with predominant phasic and tonic dystonia. / Yokochi, Fusako; Kato, Kenji; Iwamuro, Hirokazu; Kamiyama, Tsutomu; Kimura, Katsuo; Yugeta, Akihiro; Okiyama, Ryoichi; Taniguchi, Makoto; Kumada, Satoko; Ushiba, Junichi.

In: Frontiers in Neurology, Vol. 9, No. MAY, 375, 31.05.2018.

Research output: Contribution to journalArticle

Yokochi, F, Kato, K, Iwamuro, H, Kamiyama, T, Kimura, K, Yugeta, A, Okiyama, R, Taniguchi, M, Kumada, S & Ushiba, J 2018, 'Resting-state pallidal-cortical oscillatory couplings in patients with predominant phasic and tonic dystonia', Frontiers in Neurology, vol. 9, no. MAY, 375. https://doi.org/10.3389/fneur.2018.00375
Yokochi, Fusako ; Kato, Kenji ; Iwamuro, Hirokazu ; Kamiyama, Tsutomu ; Kimura, Katsuo ; Yugeta, Akihiro ; Okiyama, Ryoichi ; Taniguchi, Makoto ; Kumada, Satoko ; Ushiba, Junichi. / Resting-state pallidal-cortical oscillatory couplings in patients with predominant phasic and tonic dystonia. In: Frontiers in Neurology. 2018 ; Vol. 9, No. MAY.
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