Restricted diffusion in the corpus callosum in hypoxic-ischemic encephalopathy

Toshiki Takenouchi, Linda A. Heier, Murray Engel, Jeffrey M. Perlman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Restricted diffusion within the splenium of the corpus callosum was described in various conditions, but is not a prominent finding in magnetic resonance imaging after neonatal hypoxic-ischemic encephalopathy. Perinatal characteristics were reviewed in 42 term neonates with hypoxic-ischemic encephalopathy treated with selective head cooling. Neonatal images of 34 infants were reviewed. Ten of 34 (29%) infants demonstrated restricted diffusion changes within the splenium of the corpus callosum, with a significantly higher incidence of death or severe developmental delay, compared with infants without changes in the splenium of the corpus callosum (n = 24) (P = 0.002). The positive predictive value of changes in the splenium of the corpus callosum regarding poor outcomes or death was 90%. Changes in the splenium of the corpus callosum were also associated with lower birth weights, larger base deficits in cord arterial gas, and more severe encephalopathy during enrollment in selective head cooling. Restricted diffusion within the splenium of the corpus callosum of term infants with hypoxic-ischemic encephalopathy is often associated with extensive brain injury, and in these circumstances appears to be an early neuroradiologic marker of adverse neurologic outcomes.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalPediatric Neurology
Volume43
Issue number3
DOIs
Publication statusPublished - 2010 Sep 1
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Restricted diffusion in the corpus callosum in hypoxic-ischemic encephalopathy'. Together they form a unique fingerprint.

Cite this