Reticuloendothelial System-Potentiating and Alkaline Phosphatase-Inducing Activities of Plantago-Mucilage A, the Main Mucilage from the Seed of Plantago asiatica, and Its Five Modification Products

Masashi Tomoda, Katsutoshi Takada, Noriko Shimizu, Ryoko Gonda, Naoko Ohara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Five kinds of chemically modified products were prepared from Plantago-mucilage A, the representative mucous polysaccharide isolated from the seed of Plantago asiatica L., and their reticuloendothelial system-potentiating and alkaline phosphatase-inducing activities have been investigated. Both activities were markedly enhanced when the mucilage was de-O-acetylated. The products obtained by periodate oxidation, controlled Smith degradation, and partial acid hydrolysis under the two conditions were not effective. Structural features of the partial hydrolyzates were elucidated, and it was shown that these products lost all 0-acetyl groups, all xylose branches and many hexuronosyl arabinose side chains.

Original languageEnglish
Pages (from-to)2068-2071
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number8
DOIs
Publication statusPublished - 1991

Keywords

  • Plantago asiatica
  • Plantago-mucilage A
  • alkaline phosphatase
  • chemical modification
  • deacetylation effect
  • immunological activity
  • polysaccharide
  • reticuloendothelial system
  • seed

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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