Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice

Jun Ichiro Shimada, Junko Taniguchi, Masahiro Mori, Yasunori Sato, Hiroyuki Takuwa, Hiroshi Ito, Satoshi Kuwabara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Retinol palmitate, an analog of vitamin A, plays multiple roles in the nervous system, including neural differentiation, axon outgrowth, and neural patterning, and is also an antioxidative agent and thereby potential neuroprotectant for brain ischemia. The present study aimed at investigating the protective effects of retinol palmitate against ischemia-induced brain injury in a bilateral common carotid artery occlusion (BCCAO) model in mice. Ischemia induced by 20-min BCCAO resulted in significant neuronal morphological changes and reactive astrocyte proliferation in the hippocampus, particularly in the CA1 region, and these changes were accompanied by increased Notch1 expression. Intraperitoneal retinol palmitate administration before ischemia reduced ischemic neurons with Notch1 expression; the differences were statistically significant in both the 1.2. mg/kg group and 12. mg/kg group. These results show that retinol palmitate prevents brain ischemia-induced neuronal injury with Notch1 expression and that Notch1 signaling could be involved in the neuroprotective mechanism. Retinol palmitate could be a treatment option for human brain infarction.

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalExperimental Neurology
Volume247
DOIs
Publication statusPublished - 2013 Sep 1
Externally publishedYes

Fingerprint

Ischemia
Neurons
Common Carotid Artery
Brain Ischemia
Brain Infarction
Neuroprotective Agents
Vitamin A
Astrocytes
Brain Injuries
Nervous System
Hippocampus
retinol palmitate
Wounds and Injuries

Keywords

  • Brain infarction
  • Ischemia
  • Neuroprotection
  • Notch1
  • Retinol palmitate

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice. / Shimada, Jun Ichiro; Taniguchi, Junko; Mori, Masahiro; Sato, Yasunori; Takuwa, Hiroyuki; Ito, Hiroshi; Kuwabara, Satoshi.

In: Experimental Neurology, Vol. 247, 01.09.2013, p. 182-187.

Research output: Contribution to journalArticle

Shimada, Jun Ichiro ; Taniguchi, Junko ; Mori, Masahiro ; Sato, Yasunori ; Takuwa, Hiroyuki ; Ito, Hiroshi ; Kuwabara, Satoshi. / Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice. In: Experimental Neurology. 2013 ; Vol. 247. pp. 182-187.
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