Retinopathy: An overlooked adverse effect of interferon-beta treatment of multiple sclerosis

Masayuki Ohira, Daisuke Ito, Toshihiko Shimizu, Mamoru Shibata, Hisao Ohde, Norihiro Suzuki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Interferon (IFN), which is an established maintaining therapy for multiple sclerosis (MS), has been reported various adverse effects. This paper describes a case of IFN-associated retinopathy, representing an overlooked adverse effect in MS. A 46-year-old woman with diabetes mellitus was diagnosed with MS and treated with IFNβ-1b for three years. She displayed sudden defect of the visual field and ocular fundi showed retinal cotton wool spots indicating IFN-retinopathy, which resolved rapidly after IFN was discontinued. To evaluate the prevalence of retinopathy in MS, we performed fundoscopic examination on twenty MS patients treated with IFNβ-1b in our hospital. However, none of the patients displayed retinopathy. Only four other cases of IFN- retinopathy in MS have been reported in the literature. Therefore, IFN-retinopathy may be uncommon in MS, but neurologist should be mindful of this adverse effect and regularly check the fundus, particularly in patients with possible risk factor, diabetes mellitus.

Original languageEnglish
Pages (from-to)54-56
Number of pages3
JournalKeio Journal of Medicine
Volume58
Issue number1
DOIs
Publication statusPublished - 2009 Mar

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Interferon-beta
Interferons
Multiple Sclerosis
Therapeutics
Diabetes Mellitus
Wool
Visual Fields

Keywords

  • Adverse effect
  • Interferon
  • Multiple sclerosis
  • Retinopathy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Retinopathy : An overlooked adverse effect of interferon-beta treatment of multiple sclerosis. / Ohira, Masayuki; Ito, Daisuke; Shimizu, Toshihiko; Shibata, Mamoru; Ohde, Hisao; Suzuki, Norihiro.

In: Keio Journal of Medicine, Vol. 58, No. 1, 03.2009, p. 54-56.

Research output: Contribution to journalArticle

Ohira, Masayuki ; Ito, Daisuke ; Shimizu, Toshihiko ; Shibata, Mamoru ; Ohde, Hisao ; Suzuki, Norihiro. / Retinopathy : An overlooked adverse effect of interferon-beta treatment of multiple sclerosis. In: Keio Journal of Medicine. 2009 ; Vol. 58, No. 1. pp. 54-56.
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