Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia

Kazutomo Yamasaki, Toshiyuki Matsui, Takashi Hisabe, Yutaka Yano, Fumihito Hirai, Tsuyoshi Morokuma, Yasushi Iwao, Takayuki Matsumoto, Hidehisa Ohi, Akira Andoh, Motohiro Esaki, Kunihiko Aoyagi, Akira Sugita, Hiroshi Nakase, Mikihiro Fujiya, Daijiro Higashi, Kitaro Futami

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: This study used a multicenter questionnaire survey to evaluate the morphology and progression of the initial lesion in cases of colitis-associated colorectal neoplasia (CRN). Patients and Methods: Endoscopic images of lesions that had been definitively diagnosed as CRN by pathological examination were retrospectively reviewed. Results: This resulted in the identification of 54 initial lesions in 49 patients. The 54 initial lesions fell into the following categories: 22 endoscopically visible localized lesions consisting of 18 elevated lesions and 4 depressed lesions, as well as 32 lesions that were not endoscopically visible as localized and consisted of 20 active-phase mucosal lesions and 12 remission-phase mucosal lesions. Nineteen of the lesions eventually became advanced cancers, while 35 lesions eventually became early-stage cancers. The final lesions were 40 elevated lesions, 5 flat or depressed lesions and 9 stenotic lesions. The form of growth of the advanced cancers was progressive stenosis or increased elevation. For approximately 69% of the early-stage cancers, the growth form was increasing elevation or development of elevation. For 73.6% of the advanced cancers, the initial lesion underwent rapid growth and became advanced cancer within 3 years; they accounted for 25.9% of the total cancers. Approximately 40% of the initial lesions of CRN were endoscopically visible as localized lesions, while approximately 60% were judged to be inflammatory mucosal lesions. Conclusion: It will be necessary to proactively take biopsy inflammatory mucosal lesions in order to discover tumors early and periodic surveillance should be performed with the knowledge that tumors may grow very quickly.

Original languageEnglish
Pages (from-to)3731-3740
Number of pages10
JournalAnticancer Research
Volume36
Issue number7
Publication statusPublished - 2016

Fingerprint

Colitis
Growth
Neoplasms
Pathologic Constriction
Biopsy

Keywords

  • Colitis-associated colorectal neoplasia (CRN)
  • Initial lesion
  • Ulcerative colitis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Yamasaki, K., Matsui, T., Hisabe, T., Yano, Y., Hirai, F., Morokuma, T., ... Futami, K. (2016). Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia. Anticancer Research, 36(7), 3731-3740.

Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia. / Yamasaki, Kazutomo; Matsui, Toshiyuki; Hisabe, Takashi; Yano, Yutaka; Hirai, Fumihito; Morokuma, Tsuyoshi; Iwao, Yasushi; Matsumoto, Takayuki; Ohi, Hidehisa; Andoh, Akira; Esaki, Motohiro; Aoyagi, Kunihiko; Sugita, Akira; Nakase, Hiroshi; Fujiya, Mikihiro; Higashi, Daijiro; Futami, Kitaro.

In: Anticancer Research, Vol. 36, No. 7, 2016, p. 3731-3740.

Research output: Contribution to journalArticle

Yamasaki, K, Matsui, T, Hisabe, T, Yano, Y, Hirai, F, Morokuma, T, Iwao, Y, Matsumoto, T, Ohi, H, Andoh, A, Esaki, M, Aoyagi, K, Sugita, A, Nakase, H, Fujiya, M, Higashi, D & Futami, K 2016, 'Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia', Anticancer Research, vol. 36, no. 7, pp. 3731-3740.
Yamasaki K, Matsui T, Hisabe T, Yano Y, Hirai F, Morokuma T et al. Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia. Anticancer Research. 2016;36(7):3731-3740.
Yamasaki, Kazutomo ; Matsui, Toshiyuki ; Hisabe, Takashi ; Yano, Yutaka ; Hirai, Fumihito ; Morokuma, Tsuyoshi ; Iwao, Yasushi ; Matsumoto, Takayuki ; Ohi, Hidehisa ; Andoh, Akira ; Esaki, Motohiro ; Aoyagi, Kunihiko ; Sugita, Akira ; Nakase, Hiroshi ; Fujiya, Mikihiro ; Higashi, Daijiro ; Futami, Kitaro. / Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia. In: Anticancer Research. 2016 ; Vol. 36, No. 7. pp. 3731-3740.
@article{8cfd44aef09749eeb3e3fc3b5b16e960,
title = "Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia",
abstract = "Aim: This study used a multicenter questionnaire survey to evaluate the morphology and progression of the initial lesion in cases of colitis-associated colorectal neoplasia (CRN). Patients and Methods: Endoscopic images of lesions that had been definitively diagnosed as CRN by pathological examination were retrospectively reviewed. Results: This resulted in the identification of 54 initial lesions in 49 patients. The 54 initial lesions fell into the following categories: 22 endoscopically visible localized lesions consisting of 18 elevated lesions and 4 depressed lesions, as well as 32 lesions that were not endoscopically visible as localized and consisted of 20 active-phase mucosal lesions and 12 remission-phase mucosal lesions. Nineteen of the lesions eventually became advanced cancers, while 35 lesions eventually became early-stage cancers. The final lesions were 40 elevated lesions, 5 flat or depressed lesions and 9 stenotic lesions. The form of growth of the advanced cancers was progressive stenosis or increased elevation. For approximately 69{\%} of the early-stage cancers, the growth form was increasing elevation or development of elevation. For 73.6{\%} of the advanced cancers, the initial lesion underwent rapid growth and became advanced cancer within 3 years; they accounted for 25.9{\%} of the total cancers. Approximately 40{\%} of the initial lesions of CRN were endoscopically visible as localized lesions, while approximately 60{\%} were judged to be inflammatory mucosal lesions. Conclusion: It will be necessary to proactively take biopsy inflammatory mucosal lesions in order to discover tumors early and periodic surveillance should be performed with the knowledge that tumors may grow very quickly.",
keywords = "Colitis-associated colorectal neoplasia (CRN), Initial lesion, Ulcerative colitis",
author = "Kazutomo Yamasaki and Toshiyuki Matsui and Takashi Hisabe and Yutaka Yano and Fumihito Hirai and Tsuyoshi Morokuma and Yasushi Iwao and Takayuki Matsumoto and Hidehisa Ohi and Akira Andoh and Motohiro Esaki and Kunihiko Aoyagi and Akira Sugita and Hiroshi Nakase and Mikihiro Fujiya and Daijiro Higashi and Kitaro Futami",
year = "2016",
language = "English",
volume = "36",
pages = "3731--3740",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "7",

}

TY - JOUR

T1 - Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia

AU - Yamasaki, Kazutomo

AU - Matsui, Toshiyuki

AU - Hisabe, Takashi

AU - Yano, Yutaka

AU - Hirai, Fumihito

AU - Morokuma, Tsuyoshi

AU - Iwao, Yasushi

AU - Matsumoto, Takayuki

AU - Ohi, Hidehisa

AU - Andoh, Akira

AU - Esaki, Motohiro

AU - Aoyagi, Kunihiko

AU - Sugita, Akira

AU - Nakase, Hiroshi

AU - Fujiya, Mikihiro

AU - Higashi, Daijiro

AU - Futami, Kitaro

PY - 2016

Y1 - 2016

N2 - Aim: This study used a multicenter questionnaire survey to evaluate the morphology and progression of the initial lesion in cases of colitis-associated colorectal neoplasia (CRN). Patients and Methods: Endoscopic images of lesions that had been definitively diagnosed as CRN by pathological examination were retrospectively reviewed. Results: This resulted in the identification of 54 initial lesions in 49 patients. The 54 initial lesions fell into the following categories: 22 endoscopically visible localized lesions consisting of 18 elevated lesions and 4 depressed lesions, as well as 32 lesions that were not endoscopically visible as localized and consisted of 20 active-phase mucosal lesions and 12 remission-phase mucosal lesions. Nineteen of the lesions eventually became advanced cancers, while 35 lesions eventually became early-stage cancers. The final lesions were 40 elevated lesions, 5 flat or depressed lesions and 9 stenotic lesions. The form of growth of the advanced cancers was progressive stenosis or increased elevation. For approximately 69% of the early-stage cancers, the growth form was increasing elevation or development of elevation. For 73.6% of the advanced cancers, the initial lesion underwent rapid growth and became advanced cancer within 3 years; they accounted for 25.9% of the total cancers. Approximately 40% of the initial lesions of CRN were endoscopically visible as localized lesions, while approximately 60% were judged to be inflammatory mucosal lesions. Conclusion: It will be necessary to proactively take biopsy inflammatory mucosal lesions in order to discover tumors early and periodic surveillance should be performed with the knowledge that tumors may grow very quickly.

AB - Aim: This study used a multicenter questionnaire survey to evaluate the morphology and progression of the initial lesion in cases of colitis-associated colorectal neoplasia (CRN). Patients and Methods: Endoscopic images of lesions that had been definitively diagnosed as CRN by pathological examination were retrospectively reviewed. Results: This resulted in the identification of 54 initial lesions in 49 patients. The 54 initial lesions fell into the following categories: 22 endoscopically visible localized lesions consisting of 18 elevated lesions and 4 depressed lesions, as well as 32 lesions that were not endoscopically visible as localized and consisted of 20 active-phase mucosal lesions and 12 remission-phase mucosal lesions. Nineteen of the lesions eventually became advanced cancers, while 35 lesions eventually became early-stage cancers. The final lesions were 40 elevated lesions, 5 flat or depressed lesions and 9 stenotic lesions. The form of growth of the advanced cancers was progressive stenosis or increased elevation. For approximately 69% of the early-stage cancers, the growth form was increasing elevation or development of elevation. For 73.6% of the advanced cancers, the initial lesion underwent rapid growth and became advanced cancer within 3 years; they accounted for 25.9% of the total cancers. Approximately 40% of the initial lesions of CRN were endoscopically visible as localized lesions, while approximately 60% were judged to be inflammatory mucosal lesions. Conclusion: It will be necessary to proactively take biopsy inflammatory mucosal lesions in order to discover tumors early and periodic surveillance should be performed with the knowledge that tumors may grow very quickly.

KW - Colitis-associated colorectal neoplasia (CRN)

KW - Initial lesion

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=84992121083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992121083&partnerID=8YFLogxK

M3 - Article

C2 - 27354647

AN - SCOPUS:84992121083

VL - 36

SP - 3731

EP - 3740

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 7

ER -