Abstract
We retrospectively reviewed nine cases of olfactory neuroblastoma in Keio University School of Medicine from 2010 to 2015. The surgical approach was the endoscopic endonasal approach, either alone or in combination with craniotomy, performed by a team of head and neck surgeons and a neurosurgeon. The distribution of patients according to the modified Kadish classification （A/B/C/D) and Dulguerov classification （T1/T2/ T3/T4) was 1/4/4/0 and 1/4/2/2. Tumors of six cases were removed by the endoscopic endonasal approach alone; three cases needed craniotomy to resect intra-dual tumors. Three-layered skull base reconstruction using fascia, pericranial flap and nasoseptal flap was used for five cases. None of the cases experienced cerebrospinal fluid leakage postoperatively. Seven patients received postoperative radiotherapy. Three cases experienced tumor recurrence, and underwent salvage surgery or radiotherapy. All cases remained alive, though the average observation time was less than 3 years. Recent reports have demonstrated that the endoscopic endonasal approach has a comparable control rate to the open approach for olfactory neuroblastoma. We believe that endoscopic endonasal skull base surgery should play a key role in the treatment of olfactory neuroblastoma in the years ahead.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Japanese Journal of Head and Neck Cancer |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- Endoscopic endonasal skull base surgery
- Olfactory neuroblastoma
- Skull base reconstruction
ASJC Scopus subject areas
- Otorhinolaryngology
- Oncology
Cite this
Retrospective analysis of olfactory neuroblastoma cases treated with endoscopic endonasal approach. / Ozawa, Hiroyuki; Tomita, Toshiki; Watanabe, Yoshihiro; Sekimizu, Mariko; Ito, Fumihiro; Ikari, Yuichi; Saito, Shin; Sato, Yoichiro; Toda, Masahiro; Ogawa, Kaoru.
In: Japanese Journal of Head and Neck Cancer, Vol. 43, No. 1, 2017, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retrospective analysis of olfactory neuroblastoma cases treated with endoscopic endonasal approach
AU - Ozawa, Hiroyuki
AU - Tomita, Toshiki
AU - Watanabe, Yoshihiro
AU - Sekimizu, Mariko
AU - Ito, Fumihiro
AU - Ikari, Yuichi
AU - Saito, Shin
AU - Sato, Yoichiro
AU - Toda, Masahiro
AU - Ogawa, Kaoru
PY - 2017
Y1 - 2017
N2 - We retrospectively reviewed nine cases of olfactory neuroblastoma in Keio University School of Medicine from 2010 to 2015. The surgical approach was the endoscopic endonasal approach, either alone or in combination with craniotomy, performed by a team of head and neck surgeons and a neurosurgeon. The distribution of patients according to the modified Kadish classification （A/B/C/D) and Dulguerov classification （T1/T2/ T3/T4) was 1/4/4/0 and 1/4/2/2. Tumors of six cases were removed by the endoscopic endonasal approach alone; three cases needed craniotomy to resect intra-dual tumors. Three-layered skull base reconstruction using fascia, pericranial flap and nasoseptal flap was used for five cases. None of the cases experienced cerebrospinal fluid leakage postoperatively. Seven patients received postoperative radiotherapy. Three cases experienced tumor recurrence, and underwent salvage surgery or radiotherapy. All cases remained alive, though the average observation time was less than 3 years. Recent reports have demonstrated that the endoscopic endonasal approach has a comparable control rate to the open approach for olfactory neuroblastoma. We believe that endoscopic endonasal skull base surgery should play a key role in the treatment of olfactory neuroblastoma in the years ahead.
AB - We retrospectively reviewed nine cases of olfactory neuroblastoma in Keio University School of Medicine from 2010 to 2015. The surgical approach was the endoscopic endonasal approach, either alone or in combination with craniotomy, performed by a team of head and neck surgeons and a neurosurgeon. The distribution of patients according to the modified Kadish classification （A/B/C/D) and Dulguerov classification （T1/T2/ T3/T4) was 1/4/4/0 and 1/4/2/2. Tumors of six cases were removed by the endoscopic endonasal approach alone; three cases needed craniotomy to resect intra-dual tumors. Three-layered skull base reconstruction using fascia, pericranial flap and nasoseptal flap was used for five cases. None of the cases experienced cerebrospinal fluid leakage postoperatively. Seven patients received postoperative radiotherapy. Three cases experienced tumor recurrence, and underwent salvage surgery or radiotherapy. All cases remained alive, though the average observation time was less than 3 years. Recent reports have demonstrated that the endoscopic endonasal approach has a comparable control rate to the open approach for olfactory neuroblastoma. We believe that endoscopic endonasal skull base surgery should play a key role in the treatment of olfactory neuroblastoma in the years ahead.
KW - Endoscopic endonasal skull base surgery
KW - Olfactory neuroblastoma
KW - Skull base reconstruction
UR - http://www.scopus.com/inward/record.url?scp=85020890011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020890011&partnerID=8YFLogxK
U2 - 10.5981/jjhnc.43.1
DO - 10.5981/jjhnc.43.1
M3 - Article
AN - SCOPUS:85020890011
VL - 43
SP - 1
EP - 7
JO - Japanese Journal of Head and Neck Cancer
JF - Japanese Journal of Head and Neck Cancer
SN - 1349-5747
IS - 1
ER -