Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan, normal tissue complication probability model, and clinical outcomes in prostate cancer

Kyohei Fukata, Hidemasa Kawamura, Nobuteru Kubo, Tatsuaki Kanai, Masami Torikoshi, Takashi Nakano, Mutsumi Tashiro, Tatsuya Ohno

Research output: Contribution to journalArticlepeer-review

Abstract

This retrospective study assessed the treatment planning data and clinical outcomes for 152 prostate cancer patients: 76 consecutive patients treated by carbon-ion radiation therapy and 76 consequtive patients treated by moderate hypo-fractionated intensity-modulated photon radiation therapy. These two modalities were compared using linear quadratic model equivalent doses in 2 Gy per fraction for rectal or rectal wall dose–volume histogram, 3.6 Gy per fraction-converted rectal dose–volume histogram, normal tissue complication probability model, and actual clinical outcomes. Carbon-ion radiation therapy was predicted to have a lower probability of rectal adverse events than intensity-modulated photon radiation therapy based on dose–volume histograms and normal tissue complication probability model. There was no difference in the clinical outcome of rectal adverse events between the two modalities compared in this study.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalPhysica Medica
Volume90
DOIs
Publication statusPublished - 2021 Oct

Keywords

  • Carbon-ion radiation therapy
  • Normal tissue complication probability
  • Prostate cancer

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

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