Reversible Fronto-occipitotemporal Signaling Complements Task Encoding and Switching under Ambiguous Cues

Kaho Tsumura, Keita Kosugi, Yoshiki Hattori, Ryuta Aoki, Masaki Takeda, Junichi Chikazoe, Kiyoshi Nakahara, Koji Jimura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Adaptation to changing environments involves the appropriate extraction of environmental information to achieve a behavioral goal. It remains unclear how behavioral flexibility is guided under situations where the relevant behavior is ambiguous. Using functional brain mapping of machine learning decoders and directional functional connectivity, we show that brain-wide reversible neural signaling underpins task encoding and behavioral flexibility in ambiguously changing environments. When relevant behavior is cued ambiguously during behavioral shifting, neural coding is attenuated in distributed cortical regions, but top-down signals from the prefrontal cortex complement the coding. When behavioral shifting is cued more explicitly, modality-specialized occipitotemporal regions implement distinct neural coding about relevant behavior, and bottom-up signals from the occipitotemporal region to the prefrontal cortex supplement the behavioral shift. These results suggest that our adaptation to an ever-changing world is orchestrated by the alternation of top-down and bottom-up signaling in the fronto-occipitotemporal circuit depending on the availability of environmental information.

Original languageEnglish
Pages (from-to)1911-1931
Number of pages21
JournalCerebral Cortex
Volume32
Issue number9
DOIs
Publication statusPublished - 2022 May 1

Keywords

  • behavioral flexibility
  • deep neural network
  • occipitotemporal cortex
  • prefrontal cortex
  • task cue

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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