Abstract
The human uterus is composed of the endometrial lining and the myometrium. The endometrium, in particular the functionalis layer, regenerates and regresses with each menstrual cycle under hormonal control. A mouse xenograft model has been developed in which the functional changes of the endometrium are reproduced. The myometrium possesses similar plasticity, critical to permit the changes connected with uterine expansion and involution associated with pregnancy. Regeneration and remodeling in the uterus are likely achieved through endometrial and myometrial stem cell systems. Putative stem/progenitor cells in humans and rodents recently have been identified, isolated and characterized. Their roles in endometrial physiology and pathophysiology are presently under study. These stem/progenitor cells ultimately may provide a novel means by which to produce tissues and organs in vitro and in vivo.
| Original language | English |
|---|---|
| Journal | Placenta |
| Volume | 34 |
| Issue number | SUPPL |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- Endometriosis
- Endometrium
- Hypoxia
- Leiomyoma
- Myometrium
- Stem cells
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
- Developmental Biology
Cite this
Review : Human uterine stem/progenitor cells: Implications for uterine physiology and pathology. / Maruyama, Tetsuo; Miyazaki, K.; Masuda, Hirotaka; Ono, M.; Uchida, Hiroshi; Yoshimura, Y.
In: Placenta, Vol. 34, No. SUPPL, 2013.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Review
T2 - Human uterine stem/progenitor cells: Implications for uterine physiology and pathology
AU - Maruyama, Tetsuo
AU - Miyazaki, K.
AU - Masuda, Hirotaka
AU - Ono, M.
AU - Uchida, Hiroshi
AU - Yoshimura, Y.
PY - 2013
Y1 - 2013
N2 - The human uterus is composed of the endometrial lining and the myometrium. The endometrium, in particular the functionalis layer, regenerates and regresses with each menstrual cycle under hormonal control. A mouse xenograft model has been developed in which the functional changes of the endometrium are reproduced. The myometrium possesses similar plasticity, critical to permit the changes connected with uterine expansion and involution associated with pregnancy. Regeneration and remodeling in the uterus are likely achieved through endometrial and myometrial stem cell systems. Putative stem/progenitor cells in humans and rodents recently have been identified, isolated and characterized. Their roles in endometrial physiology and pathophysiology are presently under study. These stem/progenitor cells ultimately may provide a novel means by which to produce tissues and organs in vitro and in vivo.
AB - The human uterus is composed of the endometrial lining and the myometrium. The endometrium, in particular the functionalis layer, regenerates and regresses with each menstrual cycle under hormonal control. A mouse xenograft model has been developed in which the functional changes of the endometrium are reproduced. The myometrium possesses similar plasticity, critical to permit the changes connected with uterine expansion and involution associated with pregnancy. Regeneration and remodeling in the uterus are likely achieved through endometrial and myometrial stem cell systems. Putative stem/progenitor cells in humans and rodents recently have been identified, isolated and characterized. Their roles in endometrial physiology and pathophysiology are presently under study. These stem/progenitor cells ultimately may provide a novel means by which to produce tissues and organs in vitro and in vivo.
KW - Endometriosis
KW - Endometrium
KW - Hypoxia
KW - Leiomyoma
KW - Myometrium
KW - Stem cells
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UR - http://www.scopus.com/inward/citedby.url?scp=84875473870&partnerID=8YFLogxK
U2 - 10.1016/j.placenta.2012.12.010
DO - 10.1016/j.placenta.2012.12.010
M3 - Article
C2 - 23332213
AN - SCOPUS:84875473870
VL - 34
JO - Placenta
JF - Placenta
SN - 0143-4004
IS - SUPPL
ER -