Review: Human uterine stem/progenitor cells: Implications for uterine physiology and pathology

T. Maruyama; Kaoru Miyazaki; Hirotaka Masuda; M. Ono; H. Uchida; Y. Yoshimura

doi:10.1016/j.placenta.2012.12.010

Review: Human uterine stem/progenitor cells: Implications for uterine physiology and pathology

T. Maruyama, Kaoru Miyazaki, Hirotaka Masuda, M. Ono, H. Uchida, Y. Yoshimura

Department of Obstetrics and Gynecology (Obstetrics)

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The human uterus is composed of the endometrial lining and the myometrium. The endometrium, in particular the functionalis layer, regenerates and regresses with each menstrual cycle under hormonal control. A mouse xenograft model has been developed in which the functional changes of the endometrium are reproduced. The myometrium possesses similar plasticity, critical to permit the changes connected with uterine expansion and involution associated with pregnancy. Regeneration and remodeling in the uterus are likely achieved through endometrial and myometrial stem cell systems. Putative stem/progenitor cells in humans and rodents recently have been identified, isolated and characterized. Their roles in endometrial physiology and pathophysiology are presently under study. These stem/progenitor cells ultimately may provide a novel means by which to produce tissues and organs in vitro and in vivo.

Original language	English
Pages (from-to)	S68-S72
Journal	Placenta
Volume	34
Issue number	SUPPL
DOIs	https://doi.org/10.1016/j.placenta.2012.12.010
Publication status	Published - 2013

Keywords

Endometriosis
Endometrium
Hypoxia
Leiomyoma
Myometrium
Stem cells

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology
Developmental Biology

Access to Document

10.1016/j.placenta.2012.12.010

Cite this

@article{1e6f47d9c4004b8cae416de8969d16b3,

title = "Review: Human uterine stem/progenitor cells: Implications for uterine physiology and pathology",

abstract = "The human uterus is composed of the endometrial lining and the myometrium. The endometrium, in particular the functionalis layer, regenerates and regresses with each menstrual cycle under hormonal control. A mouse xenograft model has been developed in which the functional changes of the endometrium are reproduced. The myometrium possesses similar plasticity, critical to permit the changes connected with uterine expansion and involution associated with pregnancy. Regeneration and remodeling in the uterus are likely achieved through endometrial and myometrial stem cell systems. Putative stem/progenitor cells in humans and rodents recently have been identified, isolated and characterized. Their roles in endometrial physiology and pathophysiology are presently under study. These stem/progenitor cells ultimately may provide a novel means by which to produce tissues and organs in vitro and in vivo.",

keywords = "Endometriosis, Endometrium, Hypoxia, Leiomyoma, Myometrium, Stem cells",

author = "T. Maruyama and Kaoru Miyazaki and Hirotaka Masuda and M. Ono and H. Uchida and Y. Yoshimura",

note = "Funding Information: We thank members of our research group, Hideyuki Okano and Yumi Matsuzaki, for their generous assistance and collaboration with this project. We acknowledge the secretarial assistance of Rika Shibata. This work was partly supported by Grants-in-aid from the Japan Society for the Promotion of Science (to T.M. and Y.Y.); Grant-in-aid from Keio University Sakaguchi-Memorial Medical Science Fund (to T.M.); Grant-in-aid from the Japan Medical Association (to T.M.); and Grant-in-aid from the Uehara Memorial Foundation (to T.M.). ",

year = "2013",

doi = "10.1016/j.placenta.2012.12.010",

language = "English",

volume = "34",

pages = "S68--S72",

journal = "Placenta",

issn = "0143-4004",

publisher = "W.B. Saunders Ltd",

number = "SUPPL",

}

TY - JOUR

T1 - Review

T2 - Human uterine stem/progenitor cells: Implications for uterine physiology and pathology

AU - Maruyama, T.

AU - Miyazaki, Kaoru

AU - Masuda, Hirotaka

AU - Ono, M.

AU - Uchida, H.

AU - Yoshimura, Y.

N1 - Funding Information: We thank members of our research group, Hideyuki Okano and Yumi Matsuzaki, for their generous assistance and collaboration with this project. We acknowledge the secretarial assistance of Rika Shibata. This work was partly supported by Grants-in-aid from the Japan Society for the Promotion of Science (to T.M. and Y.Y.); Grant-in-aid from Keio University Sakaguchi-Memorial Medical Science Fund (to T.M.); Grant-in-aid from the Japan Medical Association (to T.M.); and Grant-in-aid from the Uehara Memorial Foundation (to T.M.).

PY - 2013

Y1 - 2013

N2 - The human uterus is composed of the endometrial lining and the myometrium. The endometrium, in particular the functionalis layer, regenerates and regresses with each menstrual cycle under hormonal control. A mouse xenograft model has been developed in which the functional changes of the endometrium are reproduced. The myometrium possesses similar plasticity, critical to permit the changes connected with uterine expansion and involution associated with pregnancy. Regeneration and remodeling in the uterus are likely achieved through endometrial and myometrial stem cell systems. Putative stem/progenitor cells in humans and rodents recently have been identified, isolated and characterized. Their roles in endometrial physiology and pathophysiology are presently under study. These stem/progenitor cells ultimately may provide a novel means by which to produce tissues and organs in vitro and in vivo.

AB - The human uterus is composed of the endometrial lining and the myometrium. The endometrium, in particular the functionalis layer, regenerates and regresses with each menstrual cycle under hormonal control. A mouse xenograft model has been developed in which the functional changes of the endometrium are reproduced. The myometrium possesses similar plasticity, critical to permit the changes connected with uterine expansion and involution associated with pregnancy. Regeneration and remodeling in the uterus are likely achieved through endometrial and myometrial stem cell systems. Putative stem/progenitor cells in humans and rodents recently have been identified, isolated and characterized. Their roles in endometrial physiology and pathophysiology are presently under study. These stem/progenitor cells ultimately may provide a novel means by which to produce tissues and organs in vitro and in vivo.

KW - Endometriosis

KW - Endometrium

KW - Hypoxia

KW - Leiomyoma

KW - Myometrium

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=84875473870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875473870&partnerID=8YFLogxK

U2 - 10.1016/j.placenta.2012.12.010

DO - 10.1016/j.placenta.2012.12.010

M3 - Article

C2 - 23332213

AN - SCOPUS:84875473870

VL - 34

SP - S68-S72

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - SUPPL

ER -

Review: Human uterine stem/progenitor cells: Implications for uterine physiology and pathology

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this