Review of juxtaglomerular cell tumor with focus on pathobiological aspect

Naoto Kuroda, Hiroko Gotoda, Chisato Ohe, Shuji Mikami, Keiji Inoue, Yoji Nagashima, Fredrik Petersson, Isabel Alvarado-Cabrero, Chin Chen Pan, Ondrej Hes, Michal Michal, Zoran Gatalica

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.

Original languageEnglish
Article number80
JournalDiagnostic Pathology
Volume6
Issue number1
DOIs
Publication statusPublished - 2011 Aug 26

Fingerprint

Neoplasms
Renin
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 11
Fetal Death
Fatal Outcome
Hypokalemia
Vimentin
Capsules
Blood Vessels
Young Adult
Color
Hemorrhage
Neoplasm Metastasis
Hypertension
Pregnancy

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Kuroda, N., Gotoda, H., Ohe, C., Mikami, S., Inoue, K., Nagashima, Y., ... Gatalica, Z. (2011). Review of juxtaglomerular cell tumor with focus on pathobiological aspect. Diagnostic Pathology, 6(1), [80]. https://doi.org/10.1186/1746-1596-6-80

Review of juxtaglomerular cell tumor with focus on pathobiological aspect. / Kuroda, Naoto; Gotoda, Hiroko; Ohe, Chisato; Mikami, Shuji; Inoue, Keiji; Nagashima, Yoji; Petersson, Fredrik; Alvarado-Cabrero, Isabel; Pan, Chin Chen; Hes, Ondrej; Michal, Michal; Gatalica, Zoran.

In: Diagnostic Pathology, Vol. 6, No. 1, 80, 26.08.2011.

Research output: Contribution to journalArticle

Kuroda, N, Gotoda, H, Ohe, C, Mikami, S, Inoue, K, Nagashima, Y, Petersson, F, Alvarado-Cabrero, I, Pan, CC, Hes, O, Michal, M & Gatalica, Z 2011, 'Review of juxtaglomerular cell tumor with focus on pathobiological aspect', Diagnostic Pathology, vol. 6, no. 1, 80. https://doi.org/10.1186/1746-1596-6-80
Kuroda, Naoto ; Gotoda, Hiroko ; Ohe, Chisato ; Mikami, Shuji ; Inoue, Keiji ; Nagashima, Yoji ; Petersson, Fredrik ; Alvarado-Cabrero, Isabel ; Pan, Chin Chen ; Hes, Ondrej ; Michal, Michal ; Gatalica, Zoran. / Review of juxtaglomerular cell tumor with focus on pathobiological aspect. In: Diagnostic Pathology. 2011 ; Vol. 6, No. 1.
@article{985ed6a184814176943b8db4985ca0d9,
title = "Review of juxtaglomerular cell tumor with focus on pathobiological aspect",
abstract = "Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.",
author = "Naoto Kuroda and Hiroko Gotoda and Chisato Ohe and Shuji Mikami and Keiji Inoue and Yoji Nagashima and Fredrik Petersson and Isabel Alvarado-Cabrero and Pan, {Chin Chen} and Ondrej Hes and Michal Michal and Zoran Gatalica",
year = "2011",
month = "8",
day = "26",
doi = "10.1186/1746-1596-6-80",
language = "English",
volume = "6",
journal = "Diagnostic Pathology",
issn = "1746-1596",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Review of juxtaglomerular cell tumor with focus on pathobiological aspect

AU - Kuroda, Naoto

AU - Gotoda, Hiroko

AU - Ohe, Chisato

AU - Mikami, Shuji

AU - Inoue, Keiji

AU - Nagashima, Yoji

AU - Petersson, Fredrik

AU - Alvarado-Cabrero, Isabel

AU - Pan, Chin Chen

AU - Hes, Ondrej

AU - Michal, Michal

AU - Gatalica, Zoran

PY - 2011/8/26

Y1 - 2011/8/26

N2 - Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.

AB - Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.

UR - http://www.scopus.com/inward/record.url?scp=80052026499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052026499&partnerID=8YFLogxK

U2 - 10.1186/1746-1596-6-80

DO - 10.1186/1746-1596-6-80

M3 - Article

C2 - 21871063

AN - SCOPUS:80052026499

VL - 6

JO - Diagnostic Pathology

JF - Diagnostic Pathology

SN - 1746-1596

IS - 1

M1 - 80

ER -