Review of juxtaglomerular cell tumor with focus on pathobiological aspect

Naoto Kuroda, Hiroko Gotoda, Chisato Ohe, Shuji Mikami, Keiji Inoue, Yoji Nagashima, Fredrik Petersson, Isabel Alvarado-Cabrero, Chin Chen Pan, Ondrej Hes, Michal Michal, Zoran Gatalica

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.

Original languageEnglish
Article number80
JournalDiagnostic Pathology
Volume6
Issue number1
DOIs
Publication statusPublished - 2011 Aug 26

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Kuroda, N., Gotoda, H., Ohe, C., Mikami, S., Inoue, K., Nagashima, Y., Petersson, F., Alvarado-Cabrero, I., Pan, C. C., Hes, O., Michal, M., & Gatalica, Z. (2011). Review of juxtaglomerular cell tumor with focus on pathobiological aspect. Diagnostic Pathology, 6(1), [80]. https://doi.org/10.1186/1746-1596-6-80