Review of molecular modification techniques for improved detection of biomolecules by mass spectrometry

Aki Honda, Yoshio Suzuki, Koji Suzuki

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

After a soft ionizing method was established, MS (mass spectrometry) has become a more common tool in biochemistry because soft ionization made it possible to detect large molecules such as proteins. Many kinds of applications were established to further utilize MS for the identification or quantitation of biomolecules. In this review, we introduce recent applications with special focus on chemical modification techniques and chemical probes developed for the MS determination of biomolecules.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalAnalytica Chimica Acta
Volume623
Issue number1
DOIs
Publication statusPublished - 2008 Aug 8

Keywords

  • Biomolecules
  • Chemical modification
  • Mass probe
  • Mass spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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