Review of pulmonary toxicity of indium compounds to animals and humans

Akiyo Tanaka, Miyuki Hirata, Yutaka Kiyohara, Makiko Nakano, Kazuyuki Omae, Masaharu Shiratani, Kazunori Koga

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Due to the increased production of ITO, the potential health hazards arising from occupational exposure to this material have attracted much attention. This review consists of three parts: 1) toxic effects of indium compounds on animals, 2) toxic effects of indium compounds on humans, and 3) recommendations for preventing exposure to indium compounds in the workplace. Available data have indicated that insoluble form of indium compounds, such as ITO, indium arsenide (InAs) and indium phosphide (InP), can be toxic to animals. Furthermore, InP has demonstrated clear evidence of carcinogenic potential in long-term inhalation studies using experimental animals. As for the dangers to humans, some data are available concerning adverse health effects to workers who have been exposed to indium-containing particles. The Japan Society for Occupational Health recommended the value of 3 μg/L of indium in serum as the occupational exposure limit based on biological monitoring to preventing adverse health effects in workers resulting from occupational exposure to indium compounds. Accordingly, it is essential that much greater attention is focused on human exposure to indium compounds, and precautions against possible exposure to indium compounds are most important with regard to health management among indium-handling workers.

Original languageEnglish
Pages (from-to)2934-2936
Number of pages3
JournalThin Solid Films
Volume518
Issue number11
DOIs
Publication statusPublished - 2010 Mar 31

Keywords

  • ITO
  • Indium
  • Indium arsenide
  • Indium phosphide
  • Interstitial pneumonia
  • Pulmonary toxicity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Tanaka, A., Hirata, M., Kiyohara, Y., Nakano, M., Omae, K., Shiratani, M., & Koga, K. (2010). Review of pulmonary toxicity of indium compounds to animals and humans. Thin Solid Films, 518(11), 2934-2936. https://doi.org/10.1016/j.tsf.2009.10.123