Abstract
Renal carcinoid tumor is a rare neoplasm. In this article, we review this neoplasm with a focus on clinical and pathobiological aspects. The majority of patients present in the fourth to seventh decades, but there is no gender predilection. Clinically, patients with renal carcinoid tumor frequently present with abdominal, back or flank pain. This tumor is occasionally associated with horseshoe kidney and/or mature cystic teratoma located in the kidney. Macroscopically, these tumors are well demarcated with a lobulated appearance and yellow or tan-brown color cut surface. Microscopically, these tumors are composed of monomorphic round to polygonal cells with granular amphophilic to eosinophilic cytoplasm. Tumor cells are arranged in trabecular, ribbon-like, gyriform, insular, glandular and solid patterns. The nuclei are round to oval and with evenly distributed nuclear chromatin, frequently with a "salt and pepper"-pattern. Immunohistochemically, tumor cells demonstrate immunolabeling for chromogranin A and synaptophysin. Ultrastructurally, the neoplastic cells contain abundant dense core neurosecretory granules. In previous genetic studies, abnormalities of chromosomes 3 or 13 have been reported. The clinical behavior of renal carcinoid tumors is variable, but is more indolent than most renal cell carcinomas. Further investigations are warranted in order to elucidate the critical genetic abnormalities responsible for the pathogenesis of this rare entity in renal neoplastic pathology.
| Original language | English |
|---|---|
| Pages (from-to) | 15-21 |
| Number of pages | 7 |
| Journal | Histology and Histopathology |
| Volume | 28 |
| Issue number | 1 |
| Publication status | Published - 2013 Jan |
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Keywords
- Chromosome 3/13
- Pathology
- Renal carcinoid tumor
ASJC Scopus subject areas
- Histology
- Pathology and Forensic Medicine
Cite this
Review of renal carcinoid tumor with focus on clinical and pathobiological aspects. / Kuroda, Naoto; Tanaka, Azusa; Ohe, Chisato; Mikami, Shuji; Nagashima, Yoji; Inoue, Keiji; Shuin, Taro; Taguchi, Takahiro; Tominaga, Akira; Alvarado-Cabrero, Isabel; Petersson, Fredrik; Brunelli, Matteo; Martignoni, Guido; Michal, Michal; Hes, Ondrej.
In: Histology and Histopathology, Vol. 28, No. 1, 01.2013, p. 15-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Review of renal carcinoid tumor with focus on clinical and pathobiological aspects
AU - Kuroda, Naoto
AU - Tanaka, Azusa
AU - Ohe, Chisato
AU - Mikami, Shuji
AU - Nagashima, Yoji
AU - Inoue, Keiji
AU - Shuin, Taro
AU - Taguchi, Takahiro
AU - Tominaga, Akira
AU - Alvarado-Cabrero, Isabel
AU - Petersson, Fredrik
AU - Brunelli, Matteo
AU - Martignoni, Guido
AU - Michal, Michal
AU - Hes, Ondrej
PY - 2013/1
Y1 - 2013/1
N2 - Renal carcinoid tumor is a rare neoplasm. In this article, we review this neoplasm with a focus on clinical and pathobiological aspects. The majority of patients present in the fourth to seventh decades, but there is no gender predilection. Clinically, patients with renal carcinoid tumor frequently present with abdominal, back or flank pain. This tumor is occasionally associated with horseshoe kidney and/or mature cystic teratoma located in the kidney. Macroscopically, these tumors are well demarcated with a lobulated appearance and yellow or tan-brown color cut surface. Microscopically, these tumors are composed of monomorphic round to polygonal cells with granular amphophilic to eosinophilic cytoplasm. Tumor cells are arranged in trabecular, ribbon-like, gyriform, insular, glandular and solid patterns. The nuclei are round to oval and with evenly distributed nuclear chromatin, frequently with a "salt and pepper"-pattern. Immunohistochemically, tumor cells demonstrate immunolabeling for chromogranin A and synaptophysin. Ultrastructurally, the neoplastic cells contain abundant dense core neurosecretory granules. In previous genetic studies, abnormalities of chromosomes 3 or 13 have been reported. The clinical behavior of renal carcinoid tumors is variable, but is more indolent than most renal cell carcinomas. Further investigations are warranted in order to elucidate the critical genetic abnormalities responsible for the pathogenesis of this rare entity in renal neoplastic pathology.
AB - Renal carcinoid tumor is a rare neoplasm. In this article, we review this neoplasm with a focus on clinical and pathobiological aspects. The majority of patients present in the fourth to seventh decades, but there is no gender predilection. Clinically, patients with renal carcinoid tumor frequently present with abdominal, back or flank pain. This tumor is occasionally associated with horseshoe kidney and/or mature cystic teratoma located in the kidney. Macroscopically, these tumors are well demarcated with a lobulated appearance and yellow or tan-brown color cut surface. Microscopically, these tumors are composed of monomorphic round to polygonal cells with granular amphophilic to eosinophilic cytoplasm. Tumor cells are arranged in trabecular, ribbon-like, gyriform, insular, glandular and solid patterns. The nuclei are round to oval and with evenly distributed nuclear chromatin, frequently with a "salt and pepper"-pattern. Immunohistochemically, tumor cells demonstrate immunolabeling for chromogranin A and synaptophysin. Ultrastructurally, the neoplastic cells contain abundant dense core neurosecretory granules. In previous genetic studies, abnormalities of chromosomes 3 or 13 have been reported. The clinical behavior of renal carcinoid tumors is variable, but is more indolent than most renal cell carcinomas. Further investigations are warranted in order to elucidate the critical genetic abnormalities responsible for the pathogenesis of this rare entity in renal neoplastic pathology.
KW - Chromosome 3/13
KW - Pathology
KW - Renal carcinoid tumor
UR - http://www.scopus.com/inward/record.url?scp=84872183126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872183126&partnerID=8YFLogxK
M3 - Article
C2 - 23233056
AN - SCOPUS:84872183126
VL - 28
SP - 15
EP - 21
JO - Histology and Histopathology
JF - Histology and Histopathology
SN - 0213-3911
IS - 1
ER -