Review of renal carcinoid tumor with focus on clinical and pathobiological aspects

Naoto Kuroda, Azusa Tanaka, Chisato Ohe, Shuji Mikami, Yoji Nagashima, Keiji Inoue, Taro Shuin, Takahiro Taguchi, Akira Tominaga, Isabel Alvarado-Cabrero, Fredrik Petersson, Matteo Brunelli, Guido Martignoni, Michal Michal, Ondrej Hes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Renal carcinoid tumor is a rare neoplasm. In this article, we review this neoplasm with a focus on clinical and pathobiological aspects. The majority of patients present in the fourth to seventh decades, but there is no gender predilection. Clinically, patients with renal carcinoid tumor frequently present with abdominal, back or flank pain. This tumor is occasionally associated with horseshoe kidney and/or mature cystic teratoma located in the kidney. Macroscopically, these tumors are well demarcated with a lobulated appearance and yellow or tan-brown color cut surface. Microscopically, these tumors are composed of monomorphic round to polygonal cells with granular amphophilic to eosinophilic cytoplasm. Tumor cells are arranged in trabecular, ribbon-like, gyriform, insular, glandular and solid patterns. The nuclei are round to oval and with evenly distributed nuclear chromatin, frequently with a "salt and pepper"-pattern. Immunohistochemically, tumor cells demonstrate immunolabeling for chromogranin A and synaptophysin. Ultrastructurally, the neoplastic cells contain abundant dense core neurosecretory granules. In previous genetic studies, abnormalities of chromosomes 3 or 13 have been reported. The clinical behavior of renal carcinoid tumors is variable, but is more indolent than most renal cell carcinomas. Further investigations are warranted in order to elucidate the critical genetic abnormalities responsible for the pathogenesis of this rare entity in renal neoplastic pathology.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalHistology and Histopathology
Volume28
Issue number1
Publication statusPublished - 2013 Jan

Fingerprint

Carcinoid Tumor
Kidney
Neoplasms
Teratoma
Flank Pain
Chromogranin A
Chromosomes, Human, Pair 13
Synaptophysin
Chromosomes, Human, Pair 3
Back Pain
Renal Cell Carcinoma
Abdominal Pain
Chromatin
Cytoplasm
Color
Salts
Pathology

Keywords

  • Chromosome 3/13
  • Pathology
  • Renal carcinoid tumor

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Kuroda, N., Tanaka, A., Ohe, C., Mikami, S., Nagashima, Y., Inoue, K., ... Hes, O. (2013). Review of renal carcinoid tumor with focus on clinical and pathobiological aspects. Histology and Histopathology, 28(1), 15-21.

Review of renal carcinoid tumor with focus on clinical and pathobiological aspects. / Kuroda, Naoto; Tanaka, Azusa; Ohe, Chisato; Mikami, Shuji; Nagashima, Yoji; Inoue, Keiji; Shuin, Taro; Taguchi, Takahiro; Tominaga, Akira; Alvarado-Cabrero, Isabel; Petersson, Fredrik; Brunelli, Matteo; Martignoni, Guido; Michal, Michal; Hes, Ondrej.

In: Histology and Histopathology, Vol. 28, No. 1, 01.2013, p. 15-21.

Research output: Contribution to journalArticle

Kuroda, N, Tanaka, A, Ohe, C, Mikami, S, Nagashima, Y, Inoue, K, Shuin, T, Taguchi, T, Tominaga, A, Alvarado-Cabrero, I, Petersson, F, Brunelli, M, Martignoni, G, Michal, M & Hes, O 2013, 'Review of renal carcinoid tumor with focus on clinical and pathobiological aspects', Histology and Histopathology, vol. 28, no. 1, pp. 15-21.
Kuroda N, Tanaka A, Ohe C, Mikami S, Nagashima Y, Inoue K et al. Review of renal carcinoid tumor with focus on clinical and pathobiological aspects. Histology and Histopathology. 2013 Jan;28(1):15-21.
Kuroda, Naoto ; Tanaka, Azusa ; Ohe, Chisato ; Mikami, Shuji ; Nagashima, Yoji ; Inoue, Keiji ; Shuin, Taro ; Taguchi, Takahiro ; Tominaga, Akira ; Alvarado-Cabrero, Isabel ; Petersson, Fredrik ; Brunelli, Matteo ; Martignoni, Guido ; Michal, Michal ; Hes, Ondrej. / Review of renal carcinoid tumor with focus on clinical and pathobiological aspects. In: Histology and Histopathology. 2013 ; Vol. 28, No. 1. pp. 15-21.
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