Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Naoto Kuroda, Takashi Karashima, Keiji Inoue, Atsuko Kasajima, Chisato Ohe, Fumi Kawakami, Shuji Mikami, Keiko Matsuura, Masatsugu Moriyama, Yoji Nagashima, Fredrik Petersson, Jose I. Lopez, Ronald J. Cohen, Michal Michal, Ondrej Hes

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Rhabdoid morphology in renal cell carcinoma (RCC) may, like sarcomatoid change,be perceived as a type of dedifferentiation, and is a poor prognostic factor. Histologically,rhabdoid neoplastic cells are round to polygonal cells with globular eosinophiliccytoplasmic inclusions and eccentric vesicular nuclei and enlarged nucleoli.All types of RCC, including clear cell, papillary, chromophobe, collecting ductcarcinoma, renal medullary carcinoma, acquired cystic disease-associated RCC,ALK-positive renal cancer and unclassified RCC, may display a variably prominentrhabdoid phenotype. Immunohistochemically, the cytoplasm of rhabdoid cellsshows positivity for vimentin and/or cytokeratin. Ultrastructurally, cytoplasmicwhorls/aggregates of intermediate filaments correspond to light microscopicallyobserved inclusions. Genetically, a previous report suggests that combined loss ofBAP1 and PBRM1 may be associated with rhabdoid morphology. As with sarcomatoidchange, pathologists should describe, estimate and state the proportion oftumor cells with a rhabdoid phenotype in the routine pathology report of RCC.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalPolish Journal of Pathology
Volume66
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Keywords

  • Poor prognosis
  • Renal cell carcinoma
  • Rhabdoid features

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kuroda, N., Karashima, T., Inoue, K., Kasajima, A., Ohe, C., Kawakami, F., Mikami, S., Matsuura, K., Moriyama, M., Nagashima, Y., Petersson, F., Lopez, J. I., Cohen, R. J., Michal, M., & Hes, O. (2015). Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects. Polish Journal of Pathology, 66(1), 3-8. https://doi.org/10.5114/pjp.2015.51147