Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects

Naoto Kuroda, Hirofumi Matsumoto, Chisato Ohe, Shuji Mikami, Yoji Nagashima, Keiji Inoue, Delia Perez-Montiel, Fredrik Petersson, Michal Michal, Ondrej Hes, Ximing J. Yang

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Tubulocystic carcinoma of the kidney (TCK) is a recently established entity in renal neoplastic pathology. This review aims to give an overview of the clinical and pathobiological aspects of TCK. Grossly, the TCKs are well-demarcated multicystic lesions giving a "wrapped bubble" or "spongy" appearance. Microscopically, the tumors are composed of multiple, variably sized cysts separated by thin fibrous septa lacking ovarian stroma or desmoplastic reaction. The cysts are lined by tumor cells with eosinophilic cytoplasm and nuclear atypia of variable, but not infrequently of high grade corresponding to Fuhrman grade 3. A frequent association with papillary tumors has been reported. Recentmolecular genetic studies of TCK have revealed distinct features separating this subset of renal cell carcinomas (RCCs) from other types of renal tumors including collecting duct carcinoma of Bellini and renalmedullary carcinoma as well as pointing towards a close kinship with papillary RCC. Tubulocystic carcinoma of the kidney generally pursues an indolent clinical course. However, several cases with aggressive clinical behavior have been reported.We strongly feel that there is enough clinicopathological evidence to corroborate TCK as a separate entity and that it should be incorporated into the nextWHO classification of renal tumors as a separate neoplastic category.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalPolish Journal of Pathology
Volume64
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • Kidney
  • New entity
  • Tubulocystic carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects'. Together they form a unique fingerprint.

  • Cite this

    Kuroda, N., Matsumoto, H., Ohe, C., Mikami, S., Nagashima, Y., Inoue, K., Perez-Montiel, D., Petersson, F., Michal, M., Hes, O., & Yang, X. J. (2013). Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects. Polish Journal of Pathology, 64(4), 233-237. https://doi.org/10.5114/PJP.2013.39329