Review organ fabrication using pigs as an in vivo bioreactor

Eiji Kobayashi, Shugo Tohyama, Keiichi Fukuda

Research output: Contribution to journalReview article

Abstract

We present the most recent research results on the creation of pigs that can accept human cells. Pigs in which grafted human cells can flourish are essential for studies of the production of human organs in the pig and for verification of the efficacy of cells and tissues of human origin for use in regenerative therapy. First, against the background of a worldwide shortage of donor organs, the need for future medical technology to produce human organs for transplantation is discussed. We then describe proofof-concept studies in small animals used to produce human organs. An overview of the history of studies examining the induction of immune tolerance by techniques involving fertilized animal eggs and the injection of human cells into fetuses or neonatal animals is also presented. Finally, current and future prospects for producing pigs that can accept human cells and tissues for experimental purposes are discussed. (DOI: 10.2302/kjm.2019-0006-OA; Keio J Med 69 (2): 30–36, June 2020).

Original languageEnglish
Pages (from-to)30-36
Number of pages7
JournalKeio Journal of Medicine
Volume69
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Donor shortage
  • In vivo bioreactor
  • Organ fabrication
  • Pig
  • Stem cell

ASJC Scopus subject areas

  • Medicine(all)

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