Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: A new classification from the European Society for Blood and Marrow Transplantation

M. Mohty, F. Malard, M. Abecassis, E. Aerts, A. S. Alaskar, M. Aljurf, M. Arat, P. Bader, F. Baron, A. Bazarbachi, D. Blaise, F. Ciceri, S. Corbacioglu, J. H. Dalle, F. Dignan, T. Fukuda, A. Huynh, T. Masszi, M. Michallet, A. NaglerM. NiChonghaile, S. Okamoto, A. Pagliuca, C. Peters, F. B. Petersen, P. G. Richardson, T. Ruutu, B. N. Savani, E. Wallhult, I. Yakoub-Agha, R. F. Duarte, E. Carreras

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Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

Original languageEnglish
Pages (from-to)906-912
Number of pages7
JournalBone Marrow Transplantation
Volume51
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Mohty, M., Malard, F., Abecassis, M., Aerts, E., Alaskar, A. S., Aljurf, M., Arat, M., Bader, P., Baron, F., Bazarbachi, A., Blaise, D., Ciceri, F., Corbacioglu, S., Dalle, J. H., Dignan, F., Fukuda, T., Huynh, A., Masszi, T., Michallet, M., ... Carreras, E. (2016). Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: A new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplantation, 51(7), 906-912. https://doi.org/10.1038/bmt.2016.130