Revised structure and synthesis of celastramycin A, A potent innate immune suppressor

Haruhisa Kikuchi, Mizuki Sekiya, Yasuhiro Katou, Kazunori Ueda, Takahiro Kabeya, Shoichiro Kurata, Oshiteru Oshima

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

After searching for natural substances that regulate Innate Immunity using the ex vivo Drosophila culture system, a benzoyl pyrrole-type compound, celastramycin A, was Identified and Isolated as a potent suppressor. By synthesizing the previously reported structure 1 and another benzoyl pyrrole-type compound 2 reported In a Japanese patent, the correct structure of celastramycin A was confirmed to be 2. Compound 2 suppressed the production of IL-8 (IC50 0.06 μg/mL) In human umbilical vein endothelial cells (HUVECs).

Original languageEnglish
Pages (from-to)1693-1695
Number of pages3
JournalOrganic Letters
Volume11
Issue number8
DOIs
Publication statusPublished - 2009 Apr 16
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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