After searching for natural substances that regulate Innate Immunity using the ex vivo Drosophila culture system, a benzoyl pyrrole-type compound, celastramycin A, was Identified and Isolated as a potent suppressor. By synthesizing the previously reported structure 1 and another benzoyl pyrrole-type compound 2 reported In a Japanese patent, the correct structure of celastramycin A was confirmed to be 2. Compound 2 suppressed the production of IL-8 (IC50 0.06 μg/mL) In human umbilical vein endothelial cells (HUVECs).
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry