Revolutionary change in rheumatoid arthritis management with biological therapy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Biological agents targeting a specific molecule have extraordinarily fine specificity and powerful functional capabilities. By the introduction of biological therapy, management of rheumatoid arthritis has undergone a revolution and a paradigm shift. In this review, I will summarize the role in the pathogenesis of rheumatoid arthritis of the molecules targeted by biological agents. Providing evidence obtained in clinical trials and investigator-initiated clinical studies in Japan, the effectiveness and safety of biological therapy in rheumatoid arthritis are discussed. Finally, studies aiming at a personalized strategy with biological agents are listed and the future perspectives toward tailor-made medicine in the field of rheumatology are discussed.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalKeio Journal of Medicine
Volume60
Issue number3
DOIs
Publication statusPublished - 2011 Jun
Externally publishedYes

Fingerprint

Biological Therapy
Biological Factors
Rheumatoid Arthritis
Rheumatology
Japan
Research Personnel
Medicine
Clinical Trials
Safety

Keywords

  • IL-6
  • Remission
  • Safety
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Revolutionary change in rheumatoid arthritis management with biological therapy. / Takeuchi, Tsutomu.

In: Keio Journal of Medicine, Vol. 60, No. 3, 06.2011, p. 75-81.

Research output: Contribution to journalArticle

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