RHO gene products, putative small GTP-binding proteins, are important for activation of the CAL1/CDC43 gene product, a protein geranylgeranyltransferase in Saccharomyces cervisiae

H. Qadota, I. Ishii, A. Fujiyama, Y. Ohya, Y. Anraku

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Two multicopy suppressors of the cal1-1 mutation in the yeast Saccharomyces cerevisiae have been isolated and characterized. They are identical to the yeast RHO1 and RHO2 genes, which encode putative small GTP-binding proteins. Multiple copies of either RHO gene suppressed temperature-sensitive growth of the cal1-1 mutant but did not suppress the cal1 null mutant. Genetic analysis suggests that overproduction of either RHO gene product acts for activation of the CAL1 gene product.

Original languageEnglish
Pages (from-to)735-741
Number of pages7
JournalYeast
Volume8
Issue number9
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Saccharomyces
protein products
G-proteins
GTP-Binding Proteins
Genes
Chemical activation
Yeast
Proteins
Yeasts
yeasts
mutants
gene activation
genes
Transcriptional Activation
Saccharomyces cerevisiae
genetic techniques and protocols
mutation
Mutation
Temperature
Growth

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Bioengineering
  • Microbiology

Cite this

RHO gene products, putative small GTP-binding proteins, are important for activation of the CAL1/CDC43 gene product, a protein geranylgeranyltransferase in Saccharomyces cervisiae. / Qadota, H.; Ishii, I.; Fujiyama, A.; Ohya, Y.; Anraku, Y.

In: Yeast, Vol. 8, No. 9, 1992, p. 735-741.

Research output: Contribution to journalArticle

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AU - Anraku, Y.

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