RHO gene products, putative small GTP‐binding proteins, are importnat for activation of the CAL1/CDC43 gene product, a protein geranylgeranyltransferase in Saccharomyces cerevisiae

Hiroshi Qadota, Isao Ishii, Asao Fujiyama, Yoshikazu Ohya, Yasuhiro Anraku

Research output: Contribution to journalArticle

51 Citations (Scopus)


Two multicopy suppressors of the call‐1 mutation in the yeast Saccharomyces cerevisiae have been isolated and characterized. They are identical to the yeast RHO1 and RHO2 genes, which encode putative small GTP‐binding proteins. Multiple copies of either RHO gene suppressed temperature‐sensitive growth of the call‐1 mutant but did not suppress the call null mutant. Genetic analysis suggests that overproduction of either RHO gene product acts for activation of the CAL1 gene product.

Original languageEnglish
Pages (from-to)735-741
Number of pages7
Issue number9
Publication statusPublished - 1992 Sep



  • CAL1/CDC43
  • Geranylgeranylation
  • RHO1
  • RHO2
  • cell cycle
  • putative small GTP‐binding proteins

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Genetics

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