Rhodium-Catalyzed Anti-Markovnikov Hydroamination of Aliphatic and Aromatic Terminal Alkynes with Aliphatic Primary Amines

Yoshihiko Morimoto, Takuya Kochi, Fumitoshi Kakiuchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Anti-Markovnikov hydroamination of both aliphatic and aromatic terminal alkynes with primary amines was achieved using an 8-quinolinolato rhodium catalyst to form aldimines and enamines in high yields. This catalytic system realized high functional group tolerance including hydroxy, bromo, cyano, and thioester groups.

Original languageEnglish
Pages (from-to)13143-13152
Number of pages10
JournalJournal of Organic Chemistry
Volume86
Issue number18
DOIs
Publication statusPublished - 2021 Sep 17

ASJC Scopus subject areas

  • Organic Chemistry

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