The reaction of 2-arylpyridines with ethylene and carbon monoxide in the presence of a catalytic amount of Rh4(CO)12 results in selective carbonylation at the ortho C-H bond. The reaction is heavily dependent on the solvents used, with DMA (N,N-dimethylacetamide) being the solvent of choice. Steric factors are also important determinants of the efficiency of the reaction.
|Number of pages||9|
|Journal||Canadian Journal of Chemistry|
|Publication status||Published - 2005 Jun 1|
- C-H bond activation
- Carbon monoxide
ASJC Scopus subject areas
- Organic Chemistry