Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group

Yutaka Ishii, Naoto Chatani, Fumitoshi Kakiuchi, Shinji Murai

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The reaction of N-acylpiperazines with CO (15 atm) and ethylene at 160°C in the presence of Rh4(CO)12 results in dehydrogenation and carbonylation at a C-H bond. This reaction represents the first example of carbonylation at a C-H bond promoted by an oxygen functional group.

Original languageEnglish
Pages (from-to)7565-7568
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number43
DOIs
Publication statusPublished - 1997 Oct 27
Externally publishedYes

Fingerprint

Carbonylation
Rhodium
Carbon Monoxide
Dehydrogenation
Functional groups
Oxygen
ethylene

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group. / Ishii, Yutaka; Chatani, Naoto; Kakiuchi, Fumitoshi; Murai, Shinji.

In: Tetrahedron Letters, Vol. 38, No. 43, 27.10.1997, p. 7565-7568.

Research output: Contribution to journalArticle

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