(+)-Rhododendrol and epi-rhododendrin suppress the no production by activated macrophages in vivo

Shinji Fushiya, Yasuaki Kabe, Yasuaki Ikegaya, Fumihide Takano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In this study, we investigated the effect of (+)-rhododendrol (1) and epi-rhododendrin (2) isolated from Acer nikoense Maxim. (Aceraceae) on nitric oxide (NO) production in mouse peritoneal macrophages elicited by bacillus Calmette-Guerin and in vitro stimulated by lipopolysaccharide. The NO production was not affected by an oral administration of methanol extract at a dose of 100 mg/kg/day. However, the AcOEt soluble fraction significantly reduced the NO production. (+)-Rhododendrol (1) isolated as an active substance from the AcOEt fraction suppressed the NO production. epi- Rhododendrin (2), the glucoside of (+)-rhododendrol (1) isolated from the n- BuOH fraction, also suppressed the NO production. As NO is one of the critical mediators in inflammation, these results suggest that (+)- rhododendrol (1) and epi-rhododendrin (2) contribute in part to the anti- inflammatory effect of A. nikoense.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalPlanta Medica
Volume64
Issue number7
DOIs
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Macrophages
nitric oxide
Nitric Oxide
macrophages
Aceraceae
Acer
Mycobacterium bovis BCG
Inflammation Mediators
Sapindaceae
Glucosides
Peritoneal Macrophages
Bacilli
Mycobacterium bovis
anti-inflammatory activity
lipopolysaccharides
oral administration
glucosides
Oral Administration
Methanol
Lipopolysaccharides

Keywords

  • (+)-rhododendrol
  • Acer nikoense
  • Aceraceae
  • Epirhododendrin
  • Inflammation
  • Macrophage
  • Nitric oxide

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

(+)-Rhododendrol and epi-rhododendrin suppress the no production by activated macrophages in vivo. / Fushiya, Shinji; Kabe, Yasuaki; Ikegaya, Yasuaki; Takano, Fumihide.

In: Planta Medica, Vol. 64, No. 7, 1998, p. 598-602.

Research output: Contribution to journalArticle

Fushiya, Shinji ; Kabe, Yasuaki ; Ikegaya, Yasuaki ; Takano, Fumihide. / (+)-Rhododendrol and epi-rhododendrin suppress the no production by activated macrophages in vivo. In: Planta Medica. 1998 ; Vol. 64, No. 7. pp. 598-602.
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