Rikkunshito as a Therapeautic Agent for Functional Dyspepsia and its Prokinetic and Non-Prokinetic Effects

Kazumi Inokuchi, Tatsuhiro Masaoka, Takanori Kanai

Research output: Contribution to journalReview articlepeer-review

Abstract

Prokinetics is one of the therapeutic agents for functional and motility disorders of the stomach. However, its efficacy is limited. Kampo medicine is a unique medical system that was developed in Japan. In Kampo medicine, herbal medicine is prescribed based on the patient’s condition. Therefore, even for functional and motility disorders of the stomach, some herbal medicines are considered as a therapeutic option. Recently, there has been an increase in evidence for the efficacy or the mechanism of herbal medicine for functional and motility disorders of the stomach. Among these, rikkunshito is a well-studied herbal medicine that could be used as an alternative to prokinetics. In this review, we discuss the possibilities of rikkunshito for functional dyspepsia with its prokinetic and non-prokinetic effects and provide an overview of their current use with a focus on their therapeutic mechanism.

Original languageEnglish
Article number640576
JournalFrontiers in Pharmacology
Volume12
DOIs
Publication statusPublished - 2021 Jun 8

Keywords

  • functional and motility disorders of the stomach
  • functional dyspepsia
  • Kampo
  • non-prokinetic treatment
  • rikkunshito

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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