Risk factors associated with the occurrence of distal radius fractures in Japanese patients with rheumatoid arthritis

A prospective observational cohort study

Kensuke Ochi, Yuki Go, Takefumi Furuya, Katsunori Ikari, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Momohara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aims of this study were to evaluate the association between potential risk factors and the occurrence of distal radius fractures in Japanese patients with rheumatoid arthritis (RA). A total of 9,987 patients (82.0 % female; mean age, 55.7 years) with RA were enrolled in a prospective, observational study from 2000 to 2011. Self-reported distal radius fractures were verified using patient medical records. Cox proportional hazards models were used to analyze independent contributions of various risk factors to distal radius fracture occurrence. During a mean follow-up of 5.7 years, 139 patients reported 153 distal radius fractures. Among these patients, 85 distal radius fractures following minor trauma in 85 patients (6 men, 79 women) were verified with medical records. Female gender (hazard ratio [HR], 2.96; 95 % confidence interval [CI], 1.18-7.45; P∈=∈0.021), age (per 10 years, HR 1.55; 95 % CI, 1.24-1.95, P∈=∈0.00016), body mass index (BMI) (per 1 kg/m 2, HR, 1.11; 95 % CI, 1.03-1.19; P∈=∈0.0034), daily prednisolone dose (per milligram per day, HR, 1.10; 95 % CI, 1.05-1.16; P∈=∈0.00015), and physician global visual analog scale (0-10 cm, HR, 0.98; 95 % CI, 0.96-1.00; P∈=∈0.034) were significantly associated with the occurrence of distal radius fractures in Japanese patients with RA. A reduction in the daily prednisolone dose, together with the prevention of falls in female patients of advanced age with RA and a high BMI may be important in preventing distal radius fractures.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalClinical Rheumatology
Volume33
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Radius Fractures
Observational Studies
Rheumatoid Arthritis
Cohort Studies
Confidence Intervals
Prednisolone
Medical Records
Body Mass Index
Visual Analog Scale
Proportional Hazards Models
Prospective Studies
Physicians
Wounds and Injuries

Keywords

  • Body mass index
  • Distal radius fracture
  • Japanese
  • Prednisolone
  • Rheumatoid arthritis
  • Risk factors

ASJC Scopus subject areas

  • Rheumatology

Cite this

Risk factors associated with the occurrence of distal radius fractures in Japanese patients with rheumatoid arthritis : A prospective observational cohort study. / Ochi, Kensuke; Go, Yuki; Furuya, Takefumi; Ikari, Katsunori; Taniguchi, Atsuo; Yamanaka, Hisashi; Momohara, Shigeki.

In: Clinical Rheumatology, Vol. 33, No. 4, 2014, p. 477-483.

Research output: Contribution to journalArticle

Ochi, Kensuke ; Go, Yuki ; Furuya, Takefumi ; Ikari, Katsunori ; Taniguchi, Atsuo ; Yamanaka, Hisashi ; Momohara, Shigeki. / Risk factors associated with the occurrence of distal radius fractures in Japanese patients with rheumatoid arthritis : A prospective observational cohort study. In: Clinical Rheumatology. 2014 ; Vol. 33, No. 4. pp. 477-483.
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