Risk factors for bile leakage: Latest analysis of 10 102 hepatectomies for hepatocellular carcinoma from the Japanese national clinical database

Yo ichi Yamashita, Hiroyuki Yamamoto, Hiroaki Miyata, Yoshihiro Kakeji, Yuko Kitagawa, Hiroki Yamaue, Masakazu Yamamoto, Hideo Baba

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background/Purpose: The aim of this study was to identify risk factors for bile leakage in hepatic resections without biliary reconstructions using the large Japanese national clinical database (NCD). Methods: A total of 10 102 patients who had undergone hepatic resection involving more than one segment without biliary reconstructions for hepatocellular carcinoma during 2015-2017 were enrolled. Risk factors for bile leakage, with special reference to the type of hepatic resection, were identified by multivariable logistic regression analysis. Results: Bile leakage occurred in 726 patients (7.2%). Risk factors for bile leakage were as follows: male sex (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.04-1.58), diabetes mellitus (+) (OR 1.19, 95% CI 1.01-1.39), hemoglobin <10 g/dL (OR 1.4, 95% CI 1.02-1.93), albumin <3.5 g/dL (OR 1.3, 95% CI 1.03-1.63), central bisectionectomy (OR 3.8, 95% CI 2.81-5.13), left trisectionectomy (OR 3.6, 95% CI 2.10-6.15), right anterior sectionectomy (OR 2.07, 95% CI 1.58-2.72), and S5 or S8 segmentectomy (OR 1.33, 95% CI 1.00-1.77). Conclusion: Central bisectionectomy, left trisectionectomy, and right anterior sectionectomy are high-risk types of hepatic resection for bile leakage.

Original languageEnglish
Pages (from-to)556-562
Number of pages7
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume28
Issue number7
DOIs
Publication statusPublished - 2021 Jul
Externally publishedYes

Keywords

  • bile leakage
  • hepatic resections
  • hepatocellular carcinoma
  • risk factors

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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