Abstract
Objective. The aim of this study was to evaluate the associations between potential risk factors and the occurrence of established vertebral fractures in Japanese patients with rheumatoid arthritis (RA). Methods. A total of 10,469 patients with RA were enrolled in a prospective, observational study from 2000 to 2011. Self-reported vertebral fractures were verified using patient's medical records and radiographs. Cox proportional hazards models were used to analyze independent contributions of various risk factors for established vertebral fracture occurrence. Results. During a mean follow-up of 5.8 years, established vertebral fractures in 170 patients were verified with medical records and radiographs. Multivariate Cox regression analyses estimated that the hazards ratios of sustaining vertebral fractures increased by 1.84 for female gender, 1.72 for every 10 years of increased age, 1.26 for Disease Activity Score in 28 joints (DAS28), 1.44 for Japanese Health Assessment Questionnaire-Disability Index (J-HAQ-DI), 2.21 for history of any previous fractures, and 1.09 for daily prednisolone dose (mg/day). Conclusion. We confirmed the associations between vertebral fractures and advanced age, J-HAQ-DI, and high daily prednisolone dose; and found significant correlations between vertebral fractures and female gender, DAS28, and history of any previous fracture in Japanese RA patients.
| Original language | English |
|---|---|
| Pages (from-to) | 373-378 |
| Number of pages | 6 |
| Journal | Modern Rheumatology |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 |
| Externally published | Yes |
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Keywords
- Japanese
- Prednisolone
- Rheumatoid arthritis
- Risk factors
- Vertebral fracture
ASJC Scopus subject areas
- Rheumatology
Cite this
Risk factors for established vertebral fractures in Japanese patients with rheumatoid arthritis : Results from a large prospective observational cohort study. / Ishida, Osamu; Furuya, Takefumi; Inoue, Eisuke; Ochi, Kensuke; Ikari, Katsunori; Taniguchi, Atsuo; Yamanaka, Hisashi; Momohara, Shigeki.
In: Modern Rheumatology, Vol. 25, No. 3, 2015, p. 373-378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for established vertebral fractures in Japanese patients with rheumatoid arthritis
T2 - Results from a large prospective observational cohort study
AU - Ishida, Osamu
AU - Furuya, Takefumi
AU - Inoue, Eisuke
AU - Ochi, Kensuke
AU - Ikari, Katsunori
AU - Taniguchi, Atsuo
AU - Yamanaka, Hisashi
AU - Momohara, Shigeki
PY - 2015
Y1 - 2015
N2 - Objective. The aim of this study was to evaluate the associations between potential risk factors and the occurrence of established vertebral fractures in Japanese patients with rheumatoid arthritis (RA). Methods. A total of 10,469 patients with RA were enrolled in a prospective, observational study from 2000 to 2011. Self-reported vertebral fractures were verified using patient's medical records and radiographs. Cox proportional hazards models were used to analyze independent contributions of various risk factors for established vertebral fracture occurrence. Results. During a mean follow-up of 5.8 years, established vertebral fractures in 170 patients were verified with medical records and radiographs. Multivariate Cox regression analyses estimated that the hazards ratios of sustaining vertebral fractures increased by 1.84 for female gender, 1.72 for every 10 years of increased age, 1.26 for Disease Activity Score in 28 joints (DAS28), 1.44 for Japanese Health Assessment Questionnaire-Disability Index (J-HAQ-DI), 2.21 for history of any previous fractures, and 1.09 for daily prednisolone dose (mg/day). Conclusion. We confirmed the associations between vertebral fractures and advanced age, J-HAQ-DI, and high daily prednisolone dose; and found significant correlations between vertebral fractures and female gender, DAS28, and history of any previous fracture in Japanese RA patients.
AB - Objective. The aim of this study was to evaluate the associations between potential risk factors and the occurrence of established vertebral fractures in Japanese patients with rheumatoid arthritis (RA). Methods. A total of 10,469 patients with RA were enrolled in a prospective, observational study from 2000 to 2011. Self-reported vertebral fractures were verified using patient's medical records and radiographs. Cox proportional hazards models were used to analyze independent contributions of various risk factors for established vertebral fracture occurrence. Results. During a mean follow-up of 5.8 years, established vertebral fractures in 170 patients were verified with medical records and radiographs. Multivariate Cox regression analyses estimated that the hazards ratios of sustaining vertebral fractures increased by 1.84 for female gender, 1.72 for every 10 years of increased age, 1.26 for Disease Activity Score in 28 joints (DAS28), 1.44 for Japanese Health Assessment Questionnaire-Disability Index (J-HAQ-DI), 2.21 for history of any previous fractures, and 1.09 for daily prednisolone dose (mg/day). Conclusion. We confirmed the associations between vertebral fractures and advanced age, J-HAQ-DI, and high daily prednisolone dose; and found significant correlations between vertebral fractures and female gender, DAS28, and history of any previous fracture in Japanese RA patients.
KW - Japanese
KW - Prednisolone
KW - Rheumatoid arthritis
KW - Risk factors
KW - Vertebral fracture
UR - http://www.scopus.com/inward/record.url?scp=84929464694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929464694&partnerID=8YFLogxK
U2 - 10.3109/14397595.2015.1004276
DO - 10.3109/14397595.2015.1004276
M3 - Article
C2 - 25797805
AN - SCOPUS:84929464694
VL - 25
SP - 373
EP - 378
JO - Modern Rheumatology
JF - Modern Rheumatology
SN - 1439-7595
IS - 3
ER -