@article{257bbf2b236e459ab6609806448bc840,
title = "Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients",
abstract = "Objective Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP. Methods Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Results Of the completed records on 624 type 1 AIP patients, 31 (5%) had experienced pancreatic stones. Median follow-up duration was 1853 days. Bentiromide test values at diagnosis were significantly lower, and hemoglobin A1c values after corticosteroid treatment were significantly higher in patients with pancreatic stones. Imaging results disclosed that pancreatic atrophy and hilar or intrahepatic bile duct stenosis were significantly more frequent in patients with pancreatic stone formation. Pancreatic head swelling tended to be more frequent in this group as well. On the other hand, a shorter follow-up period was associated with the nonformation of pancreatic stones. Conclusions The increased frequency of pancreatic head swelling in type 1 AIP patients exhibiting pancreatic stones indicated a propensity for pancreatic juice stasis with subsequent stone development and pancreatic dysfunction occurring over longer periods of disease duration.",
keywords = "autoimmune pancreatitis, chronic pancreatitis, pancreatic stone, risk factor",
author = "Tetsuya Ito and Shigeyuki Kawa and Akihiro Matsumoto and Kensuke Kubota and Terumi Kamisawa and Kazuichi Okazaki and Kenji Hirano and Yoshiki Hirooka and Kazushige Uchida and Atsuhiro Masuda and Hirotaka Ohara and Kyoko Shimizu and Norikazu Arakura and Atsushi Masamune and Atsushi Kanno and Junichi Sakagami and Takao Itoi and Tetsuhide Ito and Toshiharu Ueki and Takayoshi Nishino and Kazuo Inui and Nobumasa Mizuno and Hitoshi Yoshida and Masanori Sugiyama and Eisuke Iwasaki and Atsushi Irisawa and Tooru Shimosegawa and Tsutomu Chiba",
note = "Funding Information: From the *Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto; †Department of Internal Medicine, Matsumoto Dental University, Shiojiri; ‡Endoscopic Unit, Yokohama City University Hospital, Yokohama; §Department of Internal Medicine, Tokyo Komagome Metropolitan Hospital, Komagome; ||Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata; ¶Department of Gastroenterology, Tokyo Takanawa Hospital, Minato; #Department of Endoscopy, Nagoya University Hospital, Nagoya; **Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe; ††Department of Community-based Medical Education, Nagoya City University Graduate School of Medical Science, Nagoya; ‡‡Department of Gastroenterology, Tokyo Women's Medical University, Shinjuku; §§Department of Gastroenterology, Aizawa Hospital, Matsumoto; |||| Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai; ¶¶Department of Gastroenterology, Kyoto Prefectural University of Medicine, Kyoto; ##Department of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku; ***Department of Medicine & Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; †††Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino; ‡‡‡Department of Gastroenterology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo; §§§Department of Gastroenterology, Second Teaching Hospital, Fujita Health University, Toyoake; ||||||Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya; ¶¶¶Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Shinagawa; ###Department of Surgery, Kyorin University School of Medicine, Mitaka; ****Department of Gastroenterology, Keio University School of Medicine, Shijuku; ††††Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Fukushima; and ‡‡‡‡Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Received for publication April 10, 2018; accepted October 23, 2018. Address correspondence to: Tetsuya Ito, MD, PhD, Department of Gastroenterology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Nagano, Japan (e‐mail: itotetsu@shinshu-u.ac.jp). This work was supported partially by the Research Program of Intractable Disease provided by the Ministry of Health, Labor, and Welfare of Japan and in part by grants-in-aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan (23591012). The authors declare no conflict of interest. Copyright {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000001210 Bentiromide test values at diagnosis were significantly lower, and hemoglobin A1c values after corticosteroid treatment were significantly higher in patients with pancreatic stones. Imaging results disclosed that pancreatic atrophy and hilar or intrahepatic bile duct stenosis were significantly more frequent in patients with pancreatic stone formation. Pancreatic head swelling tended to be more frequent in this group as well. On the other hand, a shorter follow-up period was associated with the nonformation of pancreatic stones. Conclusions: The increased frequency of pancreatic head swelling in type 1 AIP patients exhibiting pancreatic stones indicated a propensity for pancreatic juice stasis with subsequent stone development and pancreatic dysfunction occurring over longer periods of disease duration. Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",
year = "2019",
month = jan,
day = "1",
doi = "10.1097/MPA.0000000000001210",
language = "English",
volume = "48",
pages = "49--54",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "1",
}
