Risk factors for postoperative recurrence in patients with pathologically t1 colorectal cancer

Shuji Iida, Hirotoshi Hasegawa, Koji Okabayashi, Konosuke Moritani, Makio Mukai, Yuukou Kitagawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The evolution of diagnostic procedures has resulted in an increase in early detection of pathologically T1 (pT1) colorectal cancer (CRC). However, the risk factors affecting long-term outcomes of patients with pT1 CRCs have been unclear. The aim of the present study was to identify risk factors for postoperative recurrence and overall survival in patients with pT1 CRC. Methods: Between January 1990 and January 2003, a total of 284 patients with pT1 CRC underwent radical surgery in the authors' institution. The impact of clinicopathological factors on postoperative recurrence and overall survival was estimated by univariate and multivariate analysis. Results: The median follow-up period was 55 months (interquartile range: 47.1 months). Postoperative recurrence occurred in 8 (2.8%) patients. The overall 5-year and 10-year disease-free survival rates were 98.4 and 92.7%. Multivariate analysis showed the presence of lymphatic invasion only was an independent risk factor for postoperative recurrence in pT1 CRC patients (hazard ratio: 11.622; P = 0.003). The 5-year and 10-year disease-free survival rates of the patients in N-ly- group, the N-ly + group, and the N+ group were 99.5%/98.2% and 96.3%/75.2%, and 93.3%/93.3%, respectively. Additionally, 4 of the 8 recurrences were found more than 5 years after the operation. Conclusions: Lymphatic invasion was an independent risk factor for recurrence in pT1 CRC patients.

Original languageEnglish
Pages (from-to)424-430
Number of pages7
JournalWorld Journal of Surgery
Volume36
Issue number2
DOIs
Publication statusPublished - 2012 Feb

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Colorectal Neoplasms
Recurrence
Disease-Free Survival
Multivariate Analysis
Survival Rate
Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Risk factors for postoperative recurrence in patients with pathologically t1 colorectal cancer. / Iida, Shuji; Hasegawa, Hirotoshi; Okabayashi, Koji; Moritani, Konosuke; Mukai, Makio; Kitagawa, Yuukou.

In: World Journal of Surgery, Vol. 36, No. 2, 02.2012, p. 424-430.

Research output: Contribution to journalArticle

Iida, Shuji ; Hasegawa, Hirotoshi ; Okabayashi, Koji ; Moritani, Konosuke ; Mukai, Makio ; Kitagawa, Yuukou. / Risk factors for postoperative recurrence in patients with pathologically t1 colorectal cancer. In: World Journal of Surgery. 2012 ; Vol. 36, No. 2. pp. 424-430.
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abstract = "Background: The evolution of diagnostic procedures has resulted in an increase in early detection of pathologically T1 (pT1) colorectal cancer (CRC). However, the risk factors affecting long-term outcomes of patients with pT1 CRCs have been unclear. The aim of the present study was to identify risk factors for postoperative recurrence and overall survival in patients with pT1 CRC. Methods: Between January 1990 and January 2003, a total of 284 patients with pT1 CRC underwent radical surgery in the authors' institution. The impact of clinicopathological factors on postoperative recurrence and overall survival was estimated by univariate and multivariate analysis. Results: The median follow-up period was 55 months (interquartile range: 47.1 months). Postoperative recurrence occurred in 8 (2.8{\%}) patients. The overall 5-year and 10-year disease-free survival rates were 98.4 and 92.7{\%}. Multivariate analysis showed the presence of lymphatic invasion only was an independent risk factor for postoperative recurrence in pT1 CRC patients (hazard ratio: 11.622; P = 0.003). The 5-year and 10-year disease-free survival rates of the patients in N-ly- group, the N-ly + group, and the N+ group were 99.5{\%}/98.2{\%} and 96.3{\%}/75.2{\%}, and 93.3{\%}/93.3{\%}, respectively. Additionally, 4 of the 8 recurrences were found more than 5 years after the operation. Conclusions: Lymphatic invasion was an independent risk factor for recurrence in pT1 CRC patients.",
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