Risk factors of postoperative respiratory infections in lung cancer surgery

Satoshi Shiono, Junji Yoshida, Mitsuyo Nishimura, Masaru Hagiwara, Tomoyuki Hishida, Jun Ichi Nitadori, Kanji Nagai

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

BACKGROUND: Postoperative infections have been a major issue in lung cancer surgery. We changed our perioperative prophylactic antibiotic policy to a single dose of cefazolin before and after surgery in July 2002. OBJECTIVE: To identify the risk factors of postoperative pneumonia and empyema in lung cancer patients undergoing surgical resection. METHODS: From July 1992 through September 2003, 2105 patients underwent primary lung cancer resection at our division. We reviewed 1855 eligible patients for possible risk factors of pneumonia and empyema. RESULTS: Postoperative respiratory infections developed in 69 (3.7%) patients. There were 58 (3.1%) pneumonia cases and 18 (1.0%) cases of empyema. The mortality rate was 0.8% (15 patients). Nine (0.5%) patients died from postoperative respiratory infections. Multivariate analysis showed age 75 years or older, forced expiratory volume in 1 second as a percentage of forced vital capacity (FEV1%) less than 70%, advanced pathologic stage, and induction therapy to be independent risk factors of pneumonia. For postoperative empyema, advanced age was the significant factor. Twelve of 18 patients (67%) with empyema were complicated with bronchopleural fistula. The infection incidence rate did not change significantly after we modified our prophylactic antibiotic policy to a single dose of cefazolin before and after surgery. CONCLUSIONS: Lung cancer patients with advanced age, low FEV1%, advanced pathologic stage, or induction therapy had a risk for pneumonia after lung cancer surgery. Postoperative empyema was associated with advanced age.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalJournal of Thoracic Oncology
Volume2
Issue number1
DOIs
Publication statusPublished - 2007 Jan
Externally publishedYes

Fingerprint

Respiratory Tract Infections
Empyema
Lung Neoplasms
Pneumonia
Cefazolin
Anti-Bacterial Agents
Vital Capacity
Forced Expiratory Volume
Infection
Fistula
Multivariate Analysis
Mortality
Incidence
Therapeutics

Keywords

  • Empyema
  • Lung cancer
  • Pneumonia
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Shiono, S., Yoshida, J., Nishimura, M., Hagiwara, M., Hishida, T., Nitadori, J. I., & Nagai, K. (2007). Risk factors of postoperative respiratory infections in lung cancer surgery. Journal of Thoracic Oncology, 2(1), 34-38. https://doi.org/10.1097/JTO.0b013e31802bafb6

Risk factors of postoperative respiratory infections in lung cancer surgery. / Shiono, Satoshi; Yoshida, Junji; Nishimura, Mitsuyo; Hagiwara, Masaru; Hishida, Tomoyuki; Nitadori, Jun Ichi; Nagai, Kanji.

In: Journal of Thoracic Oncology, Vol. 2, No. 1, 01.2007, p. 34-38.

Research output: Contribution to journalArticle

Shiono, S, Yoshida, J, Nishimura, M, Hagiwara, M, Hishida, T, Nitadori, JI & Nagai, K 2007, 'Risk factors of postoperative respiratory infections in lung cancer surgery', Journal of Thoracic Oncology, vol. 2, no. 1, pp. 34-38. https://doi.org/10.1097/JTO.0b013e31802bafb6
Shiono, Satoshi ; Yoshida, Junji ; Nishimura, Mitsuyo ; Hagiwara, Masaru ; Hishida, Tomoyuki ; Nitadori, Jun Ichi ; Nagai, Kanji. / Risk factors of postoperative respiratory infections in lung cancer surgery. In: Journal of Thoracic Oncology. 2007 ; Vol. 2, No. 1. pp. 34-38.
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