TY - JOUR
T1 - Risk for metabolic diseases in normal weight individuals with visceral fat accumulation
T2 - A cross-sectional study in Japan
AU - Tatsumi, Yukako
AU - Nakao, Yoko M.
AU - Masuda, Izuru
AU - Higashiyama, Aya
AU - Takegami, Misa
AU - Nishimura, Kunihiro
AU - Watanabe, Makoto
AU - Ohkubo, Takayoshi
AU - Okamura, Tomonori
AU - Miyamoto, Yoshihiro
N1 - Funding Information:
This study was supported by a grant-in-aid for Young Scientists from the Japan Society for the Promotion of Science (15H06913), a grant-in-aid from the Ministry of Health, Labour and Welfare, Health and Labour Sciences research grants, Japan (Comprehensive Research on Cardiovascular Disease, Diabetes and Life-Style Related Diseases: H27- Junkankitou (Seishuu)-Ippan-009), and an Intramural Research Fund (27-4-3) for Cardiovascular Diseases of National Cerebral and Cardiovascular Center.
Publisher Copyright:
© Published by the BMJ Publishing Group Limited.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective To investigate the association between visceral fat area (VFA) and metabolic syndrome (Mets) among normal weight Japanese. Design A cross-sectional study. Setting The health check-up centre of the Takeda Hospital group in Kyoto, Japan. Methods This study involved 1674 men and 1448 women aged 30-74years who underwent medical check-ups in 2012 in the health check-up centre. They were stratified by Body Mass Index (BMI cut-off for obesity is set at 23.0kg/m2 for Asians): normal weight 18.5-22.9kg/m2 or higher weight ≥23.0kg/m2. The age-adjusted ORs of the 2nd to 4th groups of sex-specific VFA quartiles compared with the 1st quartile for a Mets component clustering were estimated. The clustering was having two or more of the following factors: High blood pressure, high fasting blood glucose (FBG), low high-density lipoprotein cholesterol (HDL-C) and high triglycerides. Statistical analyses were conducted in 2016. Results Participants in the 2nd to 4th VFA quartiles had significantly higher clustering risks; ORs were 3.4 (1.5 to 8.0), 6.3 (2.8 to 14.2) and 9.3 (4.2 to 20.7) for normal weight participants, and 1.7 (1.2 to 2.6), 2.6 (1.8 to 3.9) and 6.0 (4.1 to 8.8) for higher weight participants, respectively. The ORs of the 4th VFA quartile for Mets components were significantly higher; ORs for normal weight participants were 2.1 (1.5 to 3.0) (high blood pressure), 2.4 (1.4 to 4.2) (high FBG), 5.2 (2.1 to 12.9) (low HDL-C) and 12.0 (5.7 to 25.3) (high triglycerides), and higher weight participants were 3.9 (2.8 to 5.5), 4.1 (2.8 to 6.2), 3.9 (2.2 to 6.9) and 5.0 (3.4 to 7.4), respectively. Conclusions Among participants with normal weight, as well as those of higher weight, dose-dependent responses were observed between VFA and risk for Mets components and the clustering among Japanese adults. VFA may be useful information for interventions to improve metabolic risk factors in people with normal weight.
AB - Objective To investigate the association between visceral fat area (VFA) and metabolic syndrome (Mets) among normal weight Japanese. Design A cross-sectional study. Setting The health check-up centre of the Takeda Hospital group in Kyoto, Japan. Methods This study involved 1674 men and 1448 women aged 30-74years who underwent medical check-ups in 2012 in the health check-up centre. They were stratified by Body Mass Index (BMI cut-off for obesity is set at 23.0kg/m2 for Asians): normal weight 18.5-22.9kg/m2 or higher weight ≥23.0kg/m2. The age-adjusted ORs of the 2nd to 4th groups of sex-specific VFA quartiles compared with the 1st quartile for a Mets component clustering were estimated. The clustering was having two or more of the following factors: High blood pressure, high fasting blood glucose (FBG), low high-density lipoprotein cholesterol (HDL-C) and high triglycerides. Statistical analyses were conducted in 2016. Results Participants in the 2nd to 4th VFA quartiles had significantly higher clustering risks; ORs were 3.4 (1.5 to 8.0), 6.3 (2.8 to 14.2) and 9.3 (4.2 to 20.7) for normal weight participants, and 1.7 (1.2 to 2.6), 2.6 (1.8 to 3.9) and 6.0 (4.1 to 8.8) for higher weight participants, respectively. The ORs of the 4th VFA quartile for Mets components were significantly higher; ORs for normal weight participants were 2.1 (1.5 to 3.0) (high blood pressure), 2.4 (1.4 to 4.2) (high FBG), 5.2 (2.1 to 12.9) (low HDL-C) and 12.0 (5.7 to 25.3) (high triglycerides), and higher weight participants were 3.9 (2.8 to 5.5), 4.1 (2.8 to 6.2), 3.9 (2.2 to 6.9) and 5.0 (3.4 to 7.4), respectively. Conclusions Among participants with normal weight, as well as those of higher weight, dose-dependent responses were observed between VFA and risk for Mets components and the clustering among Japanese adults. VFA may be useful information for interventions to improve metabolic risk factors in people with normal weight.
KW - DIABETES & ENDOCRINOLOGY
KW - PUBLIC HEALTH
KW - visceral fat
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U2 - 10.1136/bmjopen-2016-013831
DO - 10.1136/bmjopen-2016-013831
M3 - Article
C2 - 28093438
AN - SCOPUS:85010469661
VL - 7
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 1
M1 - e013831
ER -