Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: A cross-sectional study in Japan

Yukako Tatsumi, Yoko M. Nakao, Izuru Masuda, Aya Higashiyama, Misa Takegami, Kunihiro Nishimura, Makoto Watanabe, Takayoshi Ohkubo, Tomonori Okamura, Yoshihiro Miyamoto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective To investigate the association between visceral fat area (VFA) and metabolic syndrome (Mets) among normal weight Japanese. Design A cross-sectional study. Setting The health check-up centre of the Takeda Hospital group in Kyoto, Japan. Methods This study involved 1674 men and 1448 women aged 30-74years who underwent medical check-ups in 2012 in the health check-up centre. They were stratified by Body Mass Index (BMI cut-off for obesity is set at 23.0kg/m2 for Asians): normal weight 18.5-22.9kg/m2 or higher weight ≥23.0kg/m2. The age-adjusted ORs of the 2nd to 4th groups of sex-specific VFA quartiles compared with the 1st quartile for a Mets component clustering were estimated. The clustering was having two or more of the following factors: High blood pressure, high fasting blood glucose (FBG), low high-density lipoprotein cholesterol (HDL-C) and high triglycerides. Statistical analyses were conducted in 2016. Results Participants in the 2nd to 4th VFA quartiles had significantly higher clustering risks; ORs were 3.4 (1.5 to 8.0), 6.3 (2.8 to 14.2) and 9.3 (4.2 to 20.7) for normal weight participants, and 1.7 (1.2 to 2.6), 2.6 (1.8 to 3.9) and 6.0 (4.1 to 8.8) for higher weight participants, respectively. The ORs of the 4th VFA quartile for Mets components were significantly higher; ORs for normal weight participants were 2.1 (1.5 to 3.0) (high blood pressure), 2.4 (1.4 to 4.2) (high FBG), 5.2 (2.1 to 12.9) (low HDL-C) and 12.0 (5.7 to 25.3) (high triglycerides), and higher weight participants were 3.9 (2.8 to 5.5), 4.1 (2.8 to 6.2), 3.9 (2.2 to 6.9) and 5.0 (3.4 to 7.4), respectively. Conclusions Among participants with normal weight, as well as those of higher weight, dose-dependent responses were observed between VFA and risk for Mets components and the clustering among Japanese adults. VFA may be useful information for interventions to improve metabolic risk factors in people with normal weight.

Original languageEnglish
Article numbere013831
JournalBMJ Open
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Intra-Abdominal Fat
Metabolic Diseases
Japan
Cross-Sectional Studies
Weights and Measures
Cluster Analysis
LDL Cholesterol
HDL Cholesterol
Blood Glucose
Fasting
Triglycerides
Hypertension
Health
Body Mass Index
Obesity

Keywords

  • DIABETES & ENDOCRINOLOGY
  • PUBLIC HEALTH
  • visceral fat

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tatsumi, Y., Nakao, Y. M., Masuda, I., Higashiyama, A., Takegami, M., Nishimura, K., ... Miyamoto, Y. (2017). Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: A cross-sectional study in Japan. BMJ Open, 7(1), [e013831]. https://doi.org/10.1136/bmjopen-2016-013831

Risk for metabolic diseases in normal weight individuals with visceral fat accumulation : A cross-sectional study in Japan. / Tatsumi, Yukako; Nakao, Yoko M.; Masuda, Izuru; Higashiyama, Aya; Takegami, Misa; Nishimura, Kunihiro; Watanabe, Makoto; Ohkubo, Takayoshi; Okamura, Tomonori; Miyamoto, Yoshihiro.

In: BMJ Open, Vol. 7, No. 1, e013831, 01.01.2017.

Research output: Contribution to journalArticle

Tatsumi, Y, Nakao, YM, Masuda, I, Higashiyama, A, Takegami, M, Nishimura, K, Watanabe, M, Ohkubo, T, Okamura, T & Miyamoto, Y 2017, 'Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: A cross-sectional study in Japan', BMJ Open, vol. 7, no. 1, e013831. https://doi.org/10.1136/bmjopen-2016-013831
Tatsumi, Yukako ; Nakao, Yoko M. ; Masuda, Izuru ; Higashiyama, Aya ; Takegami, Misa ; Nishimura, Kunihiro ; Watanabe, Makoto ; Ohkubo, Takayoshi ; Okamura, Tomonori ; Miyamoto, Yoshihiro. / Risk for metabolic diseases in normal weight individuals with visceral fat accumulation : A cross-sectional study in Japan. In: BMJ Open. 2017 ; Vol. 7, No. 1.
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abstract = "Objective To investigate the association between visceral fat area (VFA) and metabolic syndrome (Mets) among normal weight Japanese. Design A cross-sectional study. Setting The health check-up centre of the Takeda Hospital group in Kyoto, Japan. Methods This study involved 1674 men and 1448 women aged 30-74years who underwent medical check-ups in 2012 in the health check-up centre. They were stratified by Body Mass Index (BMI cut-off for obesity is set at 23.0kg/m2 for Asians): normal weight 18.5-22.9kg/m2 or higher weight ≥23.0kg/m2. The age-adjusted ORs of the 2nd to 4th groups of sex-specific VFA quartiles compared with the 1st quartile for a Mets component clustering were estimated. The clustering was having two or more of the following factors: High blood pressure, high fasting blood glucose (FBG), low high-density lipoprotein cholesterol (HDL-C) and high triglycerides. Statistical analyses were conducted in 2016. Results Participants in the 2nd to 4th VFA quartiles had significantly higher clustering risks; ORs were 3.4 (1.5 to 8.0), 6.3 (2.8 to 14.2) and 9.3 (4.2 to 20.7) for normal weight participants, and 1.7 (1.2 to 2.6), 2.6 (1.8 to 3.9) and 6.0 (4.1 to 8.8) for higher weight participants, respectively. The ORs of the 4th VFA quartile for Mets components were significantly higher; ORs for normal weight participants were 2.1 (1.5 to 3.0) (high blood pressure), 2.4 (1.4 to 4.2) (high FBG), 5.2 (2.1 to 12.9) (low HDL-C) and 12.0 (5.7 to 25.3) (high triglycerides), and higher weight participants were 3.9 (2.8 to 5.5), 4.1 (2.8 to 6.2), 3.9 (2.2 to 6.9) and 5.0 (3.4 to 7.4), respectively. Conclusions Among participants with normal weight, as well as those of higher weight, dose-dependent responses were observed between VFA and risk for Mets components and the clustering among Japanese adults. VFA may be useful information for interventions to improve metabolic risk factors in people with normal weight.",
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AU - Tatsumi, Yukako

AU - Nakao, Yoko M.

AU - Masuda, Izuru

AU - Higashiyama, Aya

AU - Takegami, Misa

AU - Nishimura, Kunihiro

AU - Watanabe, Makoto

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N2 - Objective To investigate the association between visceral fat area (VFA) and metabolic syndrome (Mets) among normal weight Japanese. Design A cross-sectional study. Setting The health check-up centre of the Takeda Hospital group in Kyoto, Japan. Methods This study involved 1674 men and 1448 women aged 30-74years who underwent medical check-ups in 2012 in the health check-up centre. They were stratified by Body Mass Index (BMI cut-off for obesity is set at 23.0kg/m2 for Asians): normal weight 18.5-22.9kg/m2 or higher weight ≥23.0kg/m2. The age-adjusted ORs of the 2nd to 4th groups of sex-specific VFA quartiles compared with the 1st quartile for a Mets component clustering were estimated. The clustering was having two or more of the following factors: High blood pressure, high fasting blood glucose (FBG), low high-density lipoprotein cholesterol (HDL-C) and high triglycerides. Statistical analyses were conducted in 2016. Results Participants in the 2nd to 4th VFA quartiles had significantly higher clustering risks; ORs were 3.4 (1.5 to 8.0), 6.3 (2.8 to 14.2) and 9.3 (4.2 to 20.7) for normal weight participants, and 1.7 (1.2 to 2.6), 2.6 (1.8 to 3.9) and 6.0 (4.1 to 8.8) for higher weight participants, respectively. The ORs of the 4th VFA quartile for Mets components were significantly higher; ORs for normal weight participants were 2.1 (1.5 to 3.0) (high blood pressure), 2.4 (1.4 to 4.2) (high FBG), 5.2 (2.1 to 12.9) (low HDL-C) and 12.0 (5.7 to 25.3) (high triglycerides), and higher weight participants were 3.9 (2.8 to 5.5), 4.1 (2.8 to 6.2), 3.9 (2.2 to 6.9) and 5.0 (3.4 to 7.4), respectively. Conclusions Among participants with normal weight, as well as those of higher weight, dose-dependent responses were observed between VFA and risk for Mets components and the clustering among Japanese adults. VFA may be useful information for interventions to improve metabolic risk factors in people with normal weight.

AB - Objective To investigate the association between visceral fat area (VFA) and metabolic syndrome (Mets) among normal weight Japanese. Design A cross-sectional study. Setting The health check-up centre of the Takeda Hospital group in Kyoto, Japan. Methods This study involved 1674 men and 1448 women aged 30-74years who underwent medical check-ups in 2012 in the health check-up centre. They were stratified by Body Mass Index (BMI cut-off for obesity is set at 23.0kg/m2 for Asians): normal weight 18.5-22.9kg/m2 or higher weight ≥23.0kg/m2. The age-adjusted ORs of the 2nd to 4th groups of sex-specific VFA quartiles compared with the 1st quartile for a Mets component clustering were estimated. The clustering was having two or more of the following factors: High blood pressure, high fasting blood glucose (FBG), low high-density lipoprotein cholesterol (HDL-C) and high triglycerides. Statistical analyses were conducted in 2016. Results Participants in the 2nd to 4th VFA quartiles had significantly higher clustering risks; ORs were 3.4 (1.5 to 8.0), 6.3 (2.8 to 14.2) and 9.3 (4.2 to 20.7) for normal weight participants, and 1.7 (1.2 to 2.6), 2.6 (1.8 to 3.9) and 6.0 (4.1 to 8.8) for higher weight participants, respectively. The ORs of the 4th VFA quartile for Mets components were significantly higher; ORs for normal weight participants were 2.1 (1.5 to 3.0) (high blood pressure), 2.4 (1.4 to 4.2) (high FBG), 5.2 (2.1 to 12.9) (low HDL-C) and 12.0 (5.7 to 25.3) (high triglycerides), and higher weight participants were 3.9 (2.8 to 5.5), 4.1 (2.8 to 6.2), 3.9 (2.2 to 6.9) and 5.0 (3.4 to 7.4), respectively. Conclusions Among participants with normal weight, as well as those of higher weight, dose-dependent responses were observed between VFA and risk for Mets components and the clustering among Japanese adults. VFA may be useful information for interventions to improve metabolic risk factors in people with normal weight.

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